Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia

被引:17
作者
Dunne, Richard F. [1 ]
Mustian, Karen M. [1 ]
Garcia, Jose M. [2 ]
Dale, William [3 ]
Hayward, Reid [4 ]
Roussel, Breton [5 ]
Buschmann, Mary M. [6 ]
Caan, Bette J. [7 ]
Cole, Calvin L. [1 ]
Fleming, Fergal J. [1 ]
Chakkalakal, Joe V. [1 ]
Linehan, David C. [1 ]
Hezel, Aram F. [1 ]
Mohile, Supriya G. [1 ]
机构
[1] Univ Rochester, Med Ctr, Wilmot Canc Inst, 601 Elmwood Ave,Box 704, Rochester, NY 14642 USA
[2] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[3] City Hope Natl Med Ctr, Dept Support Care Med, Duarte, CA USA
[4] Univ Northern Colorado, Sch Sport & Exercise Sci, Greeley, CO USA
[5] Brown Univ, Dept Med, Providence, RI 02912 USA
[6] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA
[7] Kaiser Permanente Northern Calif, Kaiser Permanente Div Res, Oakland, CA USA
关键词
cachexia; exercise; ghrelin; morphometrics; sarcopenia; ANDROGEN RECEPTOR MODULATOR; RANDOMIZED CONTROLLED-TRIAL; SKELETAL-MUSCLE; DOUBLE-BLIND; COLORECTAL-CANCER; PANCREATIC-CANCER; MEGESTROL-ACETATE; PROGNOSTIC-FACTOR; BODY-COMPOSITION; WEIGHT-LOSS;
D O I
10.1097/SPC.0000000000000301
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Purpose of review Cancer cachexia remains understudied and there are no standard treatments available despite the publication of an international consensus definition and the completion of several large phase III intervention trials in the past 6 years. In September 2015, The University of Rochester Cancer Center NCORP Research Base led a Symposium on Cancer Cachexia and Sarcopenia with goals of reviewing the state of the science, identifying knowledge gaps, and formulating research priorities in cancer cachexia through active discussion and consensus. Recent findings Research priorities that emerged from the discussion included the implementation of morphometrics into clinical decision making, establishing specific diagnostic criteria for the stages of cachexia, expanding patient selection in intervention trials, identifying clinically meaningful trial endpoints, and the investigation of exercise as an intervention for cancer cachexia. Summary Standardizing how we define and measure cancer cachexia, targeting its complex biologic mechanisms, enrolling patients early in their disease course, and evaluating exercise, either alone or in combination, were proposed as initiatives that may ultimately result in the improved design of cancer cachexia therapeutic trials.
引用
收藏
页码:278 / 286
页数:9
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