4D optical coherence tomography-based micro-angiography achieved by 1.6-MHz FDML swept source

被引：52

作者：

Zhi, Zhongwei ^{[1
]}

Qin, Wan ^{[1
]}

Wang, Jingang ^{[1
]}

Wei, Wei ^{[1
]}

Wang, Ruikang K. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Ophthalmol, Seattle, WA 98195 USA

来源：

OPTICS LETTERS | 2015年 / 40卷 / 08期

关键词：

MICROANGIOGRAPHY;

D O I：

10.1364/OL.40.001779

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate the use of an ultra-high-speed swept-source optical coherence tomography (OCT) to achieve optical micro-angiography (OMAG) of microcirculatory tissue beds in vivo. The system is based on a 1310-nm Fourier domain mode-locking (FDML) laser with 1.6-MHz A-line rate, providing a frame rate of 3.415 KHz, an axial resolution of similar to 10 mu m and signal to noise ratio of 102 dB. Motion from blood flow causes change in OCT signals between consecutive B-frames acquired at the same location. Intensity-based inter-frame subtraction algorithm is applied to extract blood flow from tissue background without any motion correction. We demonstrate the capability of this 1.6MHz OCT system for 4D OMAG of in vivo tissue at a volume rate of 4.7 volumes/s (volume size: 512 x 200 x 720 voxels). (C) 2015 Optical Society of America

引用

页码：1779 / 1782

页数：4

共 13 条

[1] Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina [J].

An, Lin ;

Shen, Tueng T. ;

Wang, Ruikang K. .

JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (10)

[2] Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds [J].

An, Lin ;

Qin, Jia ;

Wang, Ruikang K. .

OPTICS EXPRESS, 2010, 18 (08) :8220-8228

[3] OPTICAL COHERENCE TOMOGRAPHY [J].

HUANG, D ;

SWANSON, EA ;

LIN, CP ;

SCHUMAN, JS ;

STINSON, WG ;

CHANG, W ;

HEE, MR ;

FLOTTE, T ;

GREGORY, K ;

PULIAFITO, CA ;

FUJIMOTO, JG .

SCIENCE, 1991, 254 (5035) :1178-1181

[4] Graphics processing unit accelerated optical coherence tomography processing at megahertz axial scan rate and high resolution video rate volumetric rendering [J].

Jian, Yifan ;

Wong, Kevin ;

Sarunic, Marinko V. .

JOURNAL OF BIOMEDICAL OPTICS, 2013, 18 (02)

[5] Performance of fourier domain vs. time domain optical coherence tomography [J].

Leitgeb, R ;

Hitzenberger, CK ;

Fercher, AF .

OPTICS EXPRESS, 2003, 11 (08) :889-894

[6] Three dimensional optical angiography [J].

Wang, Ruikang K. ;

Jacques, Steven L. ;

Ma, Zhenhe ;

Hurst, Sawan ;

Hanson, Stephen R. ;

Gruber, Andras .

OPTICS EXPRESS, 2007, 15 (07) :4083-4097

[7] Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography [J].

Wang, Ruikang K. ;

An, Lin ;

Francis, Peter ;

Wilson, David J. .

OPTICS LETTERS, 2010, 35 (09) :1467-1469

[8] Graphics processing unit accelerated intensity-based optical coherence tomography angiography using differential frames with real-time motion correction [J].

Watanabe, Yuuki ;

Takahashi, Yuhei ;

Numazawa, Hiroshi .

JOURNAL OF BIOMEDICAL OPTICS, 2014, 19 (02)

[9] High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s [J].

Wieser, Wolfgang ;

Draxinger, Wolfgang ;

Klein, Thomas ;

Karpf, Sebastian ;

Pfeiffer, Tom ;

Huber, Robert .

BIOMEDICAL OPTICS EXPRESS, 2014, 5 (09) :2963-2977

[10] Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second [J].

Wieser, Wolfgang ;

Biedermann, Benjamin R. ;

Klein, Thomas ;

Eigenwillig, Christoph M. ;

Huber, Robert .

OPTICS EXPRESS, 2010, 18 (14) :14685-14704

← 1 2 →