CNS depressive role of aqueous extract of Spinacia oleracea L. leaves in adult male albino rats

被引：0
作者：
Das, Sutapa [1 ]
Guha, Debjani [1 ]
机构：
[1] Univ Calcutta, SN Pradhan Ctr Neurosci, Kolkata 700020, India
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2008年 / 46卷 / 03期
关键词：
anticonvulsant; epilepsy; neurotransmitters; PTZ; Spinacia oleracea;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Treatment with Spinacia oleracea extract (SO; 400 mg/kg body weight) decreased the locomotor activity, grip strength, increased pentobarbitone induced sleeping time and also markedly altered pentylenetetrazole induced seizure status in Holtzman strain adult male albino rats. SO increased serotonin level and decreased both norepinephrine and dopamine levels in cerebral cortex, cerebellum, caudate nucleus, midbrain and pons and medulla. Result suggests that SO exerts its CNS depressive effect in PTZ induced seizure by modulating the monoamines in different brain areas.
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页码：185 / 190
页数：6
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