Insulin treatment for type 2 diabetes: When to start, which to use

被引:33
作者
Hamaty, Marwan [1 ]
机构
[1] Cleveland Clin, Endocrine & Metab Inst, Ctr Diabet, Dept Endocrinol Diabet & Metab, Cleveland, OH 44195 USA
关键词
TO-TARGET TRIAL; BASAL-BOLUS REGIMEN; GLYCEMIC CONTROL; NPH INSULIN; PARALLEL-GROUP; OPEN-LABEL; SEVERE HYPOGLYCEMIA; PLUS METFORMIN; BLOOD-GLUCOSE; DOUBLE-BLIND;
D O I
10.3949/ccjm.78a.10051
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In type 2 diabetes mellitus, oral hypoglycemic agents and analogues of glucagon-like peptide-1 provide adequate glycemic control early in the disease. Insulin therapy becomes necessary for those with advanced disease. Further, some experts recommend electively starting insulin therapy in early diabetes. This review addresses practical approaches to insulin therapy, particularly when it is indicated and which regimen to use.
引用
收藏
页码:332 / 342
页数:11
相关论文
共 43 条
[1]   Frequency and risk factors of severe hypoglycemia in insulin-treated type 2 diabetes: a literature survey [J].
Akram, Kamran ;
Pedersen-Bjergaard, Ulnik ;
Borch-Johnsen, Knut ;
Thorsteinsson, Birger .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2006, 20 (06) :402-408
[2]  
Amer Diabet Assoc, 2011, DIABETES CARE, V34, pS11, DOI [10.2337/dc10-S062, 10.2337/dc14-S081, 10.2337/dc11-S011, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc10-S011, 10.2337/dc12-s011]
[3]  
[Anonymous], 1995, Diabetes, V44, P1249
[4]   Adjust to target in type 2 diabetes - Comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine [J].
Bergenstal, Richard M. ;
Johnson, Mary ;
Powers, Margaret A. ;
Wynne, Alan ;
Vlajnic, Aleksandra ;
Hollander, Priscilla ;
Rendell, Marc .
DIABETES CARE, 2008, 31 (07) :1305-1310
[5]   Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial [J].
Bretzel, Reinhard G. ;
Nuber, Ulrike ;
Landgraf, Wolfgang ;
Owens, David R. ;
Bradley, Clare ;
Linn, Thomas .
LANCET, 2008, 371 (9618) :1073-1084
[6]   DURAbility of Basal Versus Lispro Mix 75/25 Insulin Efficacy (DURABLE) Trial 24-Week Results Safety and efficacy of insulin lispro mix 75/25 versus insulin glargine added to oral antihyperglycemic drugs in patients with type 2 diabetes [J].
Buse, John B. ;
Woleeenbuttel, Bruce H. R. ;
Herman, William H. ;
Shemonsky, Natalie K. ;
Jiang, Honghua H. ;
Fahrbach, Jessie L. ;
Scism-Bacon, Jamie L. ;
Martin, Sherry A. .
DIABETES CARE, 2009, 32 (06) :1007-1013
[7]  
*CLINICALTRIALS, ORIGIN TRIAL OUTC RE
[8]  
CRYER PE, 2006, HARRISONS ENDOCRINOL, P355
[9]   Insulin glargine-based therapy improves glycemic control in patients with type 2 diabetes sub-optimally controlled on premixed insulin therapies [J].
Davies, Melanie ;
Sinnassamy, Patrick ;
Storms, Fred ;
Gomis, Ramon .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2008, 79 (02) :368-375
[10]   Glimepiride combined with morning insulin glargine, bedtime neutral protamine Hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes -: A randomized, controlled trial [J].
Fritsche, A ;
Schweitzer, MA ;
Häring, HU .
ANNALS OF INTERNAL MEDICINE, 2003, 138 (12) :952-959