3D spongy graphene-modified screen-printed sensors for the voltammetric determination of the narcotic drug codeine

被引：60

作者：

Mohamed, Mona A. ^{[1
]}

El-Gendy, Dalia M. ^{[2
]}

Ahmed, Nashaat ^{[2
]}

Banks, Craig E. ^{[3
]}

Allam, Nageh K. ^{[2
]}

机构：

[1] Natl Org Drug Control & Res, Pharmaceut Chem Dept, Pyramids Ave,POB 29, Giza, Egypt

[2] Amer Univ Cairo, Sch Sci & Engn, Energy Mat Lab, New Cairo 11835, Egypt

[3] Manchester Metropolitan Univ, Fac Sci & Engn, Chester St, Manchester M1 5GD, Lancs, England

来源：

BIOSENSORS & BIOELECTRONICS | 2018年 / 101卷

关键词：

Green synthesis; Spongy graphene; Screen-printed sensors; Codeine; Adenine; GLASSY-CARBON ELECTRODE; ELECTROCHEMICAL SENSOR; SENSITIVE DETERMINATION; PARACETAMOL; OXIDE; CAFFEINE; ACETAMINOPHEN; NANOTUBES; NANOPARTICLES; TRAMADOL;

D O I：

10.1016/j.bios.2017.10.020

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Adenine-functionalized spongy graphene (FSG) composite, fabricated via a facile and green synthetic method, has been explored as a potential electrocatalyst toward the electroanalytical sensing of codeine phosphate (COD). The synthesized composite is characterized using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray powder diffraction, UV-vis absorption spectroscopy, scanning electron microscopy, high resolution transmission electron microscopy (HRTEM), and thermogravimetric analysis. The FSG was electrically wired via modification upon screen-printed (macro electrode) sensors, which behave as a hybrid electrode material for the sensitive and selective codeine phosphate (COD) determination in the presence of paracetamol (PAR) and caffeine (CAF). The FSG- modified sensor showed an excellent electrocatalytic response towards the sensing of COD with a wide linear response range of 2.0 x 10(-8)-2.0 x 10(-4) M and a detection limit (LOD) of 5.8 x 10(-9) M, indicating its potential for the sensing of COD in clinical samples and pharmaceutical formulations.

引用

页码：90 / 95

页数：6

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