Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

被引：18

作者：

Jang, Yunseon ^{[1
,2
,3
]}

Lee, Jae Hyeon ^{[1
,3
]}

Lee, Min Joung ^{[1
,2
,3
]}

Kim, Soo Jeong ^{[1
,3
]}

Ju, Xianshu ^{[1
,2
,3
]}

Cui, Jianchen ^{[1
,2
,3
]}

Zhu, Jiebo ^{[1
,2
,3
]}

Lee, Yu Lim ^{[1
,2
,3
]}

Namgung, Eunji ^{[1
,2
,3
]}

Sung, Han Wool John ^{[1
]}

Lee, Hong Won ^{[1
]}

Ryu, Min Jeong ^{[1
]}

Oh, Eungseok ^{[4
]}

Chung, Woosuk ^{[2
,5
,6
]}

Kweon, Gi Ryang ^{[1
,2
]}

Choi, Chun Whan ^{[7
]}

Heo, Jun Young ^{[1
,2
,3
]}

机构：

[1] Chungnam Natl Univ, Sch Med, Dept Biochem, Daejeon 35015, South Korea

[2] Chungnam Natl Univ, Sch Med, Dept Med Sci, Daejeon 35015, South Korea

[3] Chungnam Natl Univ, Sch Med, Infect Control Convergence Res Ctr, Daejeon 35015, South Korea

[4] Chungnam Natl Univ Hosp, Dept Neurol, Daejeon 35015, South Korea

[5] Chungnam Natl Univ Hosp, Dept Anesthesiol & Pain Med, Daejeon 35015, South Korea

[6] Chungnam Natl Univ, Sch Med, Dept Anesthesiol & Pain Med, Daejeon 35015, South Korea

[7] Gyeonggido Business & Sci Accelerator, Bioctr, Nat Prod Res Team, Suwon 16229, South Korea

来源：

NUTRIENTS | 2020年 / 12卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

schisandra extract; ascorbic acid; mitochondria; synaptic plasticity; hippocampus; RECEPTOR SUBUNIT GLUR1; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; SYNAPTIC PLASTICITY; GREEN TEA; HIPPOCAMPUS; PSD-95; DISEASE; ROLES; SITES;

D O I：

10.3390/nu12040897

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer's disease (AD) and dementia. Intracellular energy produced via mitochondrial respiration is used in the regulation of synaptic plasticity and structure, including dendritic spine length and density, as well as for the release of neurotrophic factors involved in learning and memory. To date, a few synthetic agents for improving mitochondrial function have been developed for overcoming cognitive impairment. However, no natural compounds that modulate synaptic plasticity by directly targeting mitochondria have been developed. Here, we demonstrate that a mixture of Schisandra chinensis extract (SCE) and ascorbic acid (AA) improved cognitive function and induced synaptic plasticity-regulating proteins by enhancing mitochondrial respiration. Treatment of embryonic mouse hippocampal mHippoE-14 cells with a 4:1 mixture of SCE and AA increased basal oxygen consumption rate. We found that mice injected with the SCE-AA mixture showed enhanced learning and memory and recognition ability. We further observed that injection of the SCE-AA mixture in mice significantly increased expression of postsynaptic density protein 95 (PSD95), an increase that was correlated with enhanced brain-derived neurotrophic factor (BDNF) expression. These results demonstrate that a mixture of SCE and AA improves mitochondrial function and memory, suggesting that this natural compound mixture could be used to alleviate AD and aging-associated memory decline.

引用

页数：13

共 45 条

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