The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting

被引：23
作者：
Masgras, Ionica [1 ,2 ]
Laquatra, Claudio [1 ]
Cannino, Giuseppe [1 ]
Serapian, Stefano A. [3 ]
Colombo, Giorgio [3 ]
Rasola, Andrea [1 ]
机构：
[1] Univ Padua, Dipartimento Sci Biomed, Viale G Colombo 3, I-35131 Padua, Italy
[2] CNR, Ist Neurosci, Padua, Italy
[3] Univ Pavia, Dipartimento Chim, Via Taramelli 12, I-27100 Pavia, Italy
来源：
SEMINARS IN CANCER BIOLOGY | 2021年 / 76卷
关键词：
TRAP1; Molecular chaperone; Tumor metabolism; Mitochondria; Anti-tumor compounds; MITOCHONDRIAL PERMEABILITY TRANSITION; RECEPTOR-ASSOCIATED PROTEIN-1; HEPATOCELLULAR-CARCINOMA; CLINICAL-SIGNIFICANCE; STRUCTURAL ASYMMETRY; METABOLIC SWITCH; OXIDATIVE STRESS; HSP75; PROTECTS; HSP90; EXPRESSION;
D O I：
10.1016/j.semcancer.2021.07.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TRAP1, the mitochondrial component of the Hsp90 family of molecular chaperones, displays important bioenergetic and proteostatic functions. In tumor cells, TRAP1 contributes to shape metabolism, dynamically tuning it with the changing environmental conditions, and to shield from noxious insults. Hence, TRAP1 activity has profound effects on the capability of neoplastic cells to evolve towards more malignant phenotypes. Here, we discuss our knowledge on the biochemical functions of TRAP1 in the context of a growing tumor mass, and we analyze the possibility of targeting its chaperone functions for developing novel anti-neoplastic approaches.
引用
收藏
页码：45 / 53
页数：9
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