Two new antioxidant stilbene dimers, parthenostilbenins A and B from Parthenocissus tricuspidata

被引：59
作者：
Kim, HJ
Saleem, M
Seo, SH
Jin, C
Lee, YS
机构：
[1] Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Sci, Seoul 130701, South Korea
[2] Korea Inst Sci & Technol, Div Life Sci, Seoul 130650, South Korea
来源：
PLANTA MEDICA | 2005年 / 71卷 / 10期
关键词：
D O I：
10.1055/s-2005-871229
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The ethyl acetate fraction of an aqueous alcoholic extract from the stem of Parthenocissus tricuspidata yielded 11 known compounds (1 - 11) and two new stilbene dimers parthenostilbenins A (12) and B (13) upon purification either by preparative TLC or reversed phase HPLC. The structures of the new isolates were identified using a combination of FAB-MS and NMR. These compounds were assessed for antioxidant activities in three different bioassay systems. Among them, piceatannol showed the strongest inhibitory activity in these assay systems. Two new compounds, parthenostilbenins A (12) and B (13) inhibited lipid peroxidation (IC50 = 20.35 +/- 1.22 and 18.68 +/- 0.51 mu g/mL, respectively) in a rat liver homogenate.
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收藏
页码：973 / 976
页数：4
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