A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18

被引：35

作者：

Tozaki, T. ^{[1
]}

Hill, E. W. ^{[2
]}

Hirota, K. ^{[1
]}

Kakoi, H. ^{[3
]}

Gawahara, H. ^{[3
]}

Miyake, T. ^{[4
]}

Sugita, S. ^{[5
]}

Hasegawa, T. ^{[5
]}

Ishida, N. ^{[5
]}

Nakano, Y. ^{[6
]}

Kurosawa, M. ^{[1
]}

机构：

[1] Dept Mol Genet, Lab Racing Chem, Utsunomiya, Tochigi 3200851, Japan

[2] Univ Coll Dublin, Anim Genom Lab, Sch Agr Food Sci & Vet Med, Dublin 4, Ireland

[3] Dept Genet Anal, Lab Racing Chem, Utsunomiya, Tochigi 3200851, Japan

[4] Kyoto Univ, Grad Sch Agr, Sakyo Ku, Kyoto 6068502, Japan

[5] Japan Racing Assoc, Equine Res Inst, Utsunomiya, Tochigi 3200856, Japan

[6] Showa Univ, Sch Pharmaceut Sci, Dept Pharmacogenom, Shinagawa, Tokyo 1428555, Japan

来源：

ANIMAL GENETICS | 2012年 / 43卷 / 01期

关键词：

horse; myostatin; racing performance; retrospective cohort; Thoroughbred; LINKAGE MAP; HORSE; MSTN; SEQUENCE; GENE; ASSOCIATION; DISTANCES; STAMINA; MARKERS;

D O I：

10.1111/j.1365-2052.2011.02201.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Using 1710 Thoroughbred racehorses in Japan, a cohort study was performed to evaluate the influence of genotypes at four single nucleotide polymorphisms (SNPs) on equine chromosome 18 (ECA18), which were associated in a previous genome-wide association study for racing performance with lifetime earnings and performance rank. In males, both g.65809482T>C and g.65868604G>T were related to performance rank (P = 0.005). In females, g.65809482T>C (P = 1.76E-6), g.65868604G>T (P = 6.81E-6) and g.66493737C>T (P = 4.42E-5) were strongly related to performance rank and also to lifetime earnings (P < 0.05). When win-race distance (WRD) among all winning racehorses and best race distance (BRD) among elite racehorses were considered as the phenotypes, significant associations (P < 0.001) were observed for all four SNPs. The favourable race distance of both elite (BRD) and novice racehorses (WRD) was also associated with genotypes in the ECA18 region, indicating the presence of a gene in this region influencing optimum race distance in Thoroughbred racehorses. Therefore, the association with performance rank is likely due to the bias in the race distances. The location of the SNPs within and proximal to the gene encoding myostatin (MSTN) strongly suggests that regulation of the MSTN gene affects racing performance. In particular, the g.65809482T>C, g.65868604G>T and g.66493737C>T SNPs, or their combinations, may be genetic diagnostic markers for racing performance indicators such as WRD and BRD.

引用

页码：42 / 52

页数：11

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