HLA-DR expression is a significant prognostic factor in laryngeal cancer - A morphometric study

被引：16

作者：

Sikorska, B ^{[1
]}

Danilewicz, M ^{[1
]}

Wagrowska-Danilewicz, M ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Pathol, Lodz, Poland

来源：

APMIS | 1999年 / 107卷 / 04期

关键词：

HLA-DR; laryngeal cancer; prognosis;

D O I：

10.1111/j.1699-0463.1999.tb01569.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HLA-DR antigen expression in tumour cells was investigated in 68 laryngeal carcinomas. The tissue sections were studied by a morphometric method using a computer image analysis system. Although the highest number of HLA-DR-positive cells was observed in the groups with the lowest clinical stage, these differences did not reach statistical significance. Analysis of survival showed a significantly different survival time of patients classified as HLA-DR positive (10% and more HLA-DR+tumour cells) compared to those classified as HLA-DR negative. There were no significant differences in survival times between patients with glottic and extraglottic cancers, or between patients with various grades of histological malignancy.

引用

页码：383 / 388

页数：6

共 38 条

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ACCOLLA RS, 1991, INT J CANCER, P20

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