HIV burden in men who have sex with men: a prospective cohort study 2007-2012

被引：30

作者：

Jia, Zhongwei ^{[1
,2
,3
]}

Huang, Xiaojie ^{[4
]}

Wu, Hao ^{[4
]}

Zhang, Tong ^{[4
]}

Li, Ning ^{[4
]}

Ding, Peipei ^{[5
]}

Sun, Yixuan ^{[1
]}

Liu, Zhiying ^{[4
]}

Wei, Feili ^{[4
]}

Zhang, Hongwei ^{[4
]}

Jiao, Yanmei ^{[4
]}

Ji, Yunxia ^{[4
]}

Zhang, Yonghong ^{[4
]}

Guo, Caiping ^{[4
]}

Li, Wei ^{[4
]}

Mou, Danlei ^{[4
]}

Xia, Wei ^{[4
]}

Li, Zhen ^{[4
]}

Chen, Dexi ^{[4
]}

Yan, Huiping ^{[4
]}

Chen, Xinyue ^{[4
]}

Zhao, Jinkou ^{[6
]}

Meyers, Kathrine ^{[7
]}

Cohen, Ted ^{[8
]}

Mayer, Kenneth ^{[9
]}

Salomon, Joshua A. ^{[10
]}

Lu, Zuhong ^{[11
]}

Dye, Christopher ^{[12
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

[2] Peking Univ, Hlth Sci Ctr, Clin Res Inst, Beijing 100191, Peoples R China

[3] Harvard Univ, TH Chan Sch Publ Hlth, Takemi Program Int Hlth Global Hlth & Populat, Boston, MA 02115 USA

[4] Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing 100069, Peoples R China

[5] Beijing Normal Univ, Sch Geog, Beijing 100875, Peoples R China

[6] Global Fund Fight AIDS TB & Malaria, CH-1214 Geneva, Switzerland

[7] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[8] Harvard Univ, TH Chan Sch Publ Hlth, Epidemiol, Boston, MA 02115 USA

[9] Fenway Hlth, Fenway Inst, Boston, MA 02118 USA

[10] Harvard Univ, TH Chan Sch Publ Hlth, Global Hlth & Populat, Boston, MA 02115 USA

[11] Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China

[12] WHO, HIV AIDS TB Malaria & Neglected Trop Dis, CH-1211 Geneva 27, Switzerland

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

EPIDEMIOLOGY; INFECTION; PREVALENCE; RISK;

D O I：

10.1038/srep11205

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 enrollees who were HIV-negative at enrollment and completed at least one follow-up interview, we identified 440 incident cases of HIV in the follow up period: this constituted an HIV incidence rate of 7.1 per 100 person-years (95% CI: 6.4-7.7). Early treatment of syphilis may have significantly reduced risk of HIV infection (RR: 1.45, 95% CI: 1.11-1.93), while MSM presenting perfect compliance in the cohort did not show reduction in HIV infection. Our study suggested that HIV incidence has been remained high in this sample of Chinese MSM during the intensive preventive intervention, suggesting that we need to find new strategies to prevent HIV infection in this population.

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