The Mediator kinase module: an interface between cell signaling and transcription

被引：53

作者：

Luyties, Olivia ^{[1
]}

Taatjes, Dylan J. ^{[1
]}

机构：

[1] Univ Colorado, Dept Biochem, Boulder, CO USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2022年 / 47卷 / 04期

关键词：

HUMAN CDK8 SUBCOMPLEX; SUPER-ENHANCERS; FACTOR HOTSPOTS; CYCLIN C; MED12; ACTIVATION; ELONGATION; COMPLEX; CANCER; SWITCH;

D O I：

10.1016/j.tibs.2022.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the assembly of pol II regulatory factors at transcription start sites and by mediating interactions between enhancer-bound transcription factors (TFs) and the pol II enzyme. Mediator structure and function is completely altered upon binding the Mediator kinase module, a multi-subunit complex that contains CDK8 or its vertebrate-specific paralog CDK19. Here, we review the mechanisms by which the Mediator kinase module controls pol II transcription, emphasizing its impact on TF activity, pol II elongation, enhancer function, and chromatin architecture. We also highlight how the Mediator kinase module integrates signaling pathways with transcription to enable rapid, stimulus-specific responses, as well as its links to human disease.

引用

页码：314 / 327

页数：14

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