Programmed cell death and the caspases

被引:35
|
作者
Salvesen, GS [1 ]
机构
[1] Burnham Inst, La Jolla, CA 92037 USA
关键词
caspase; apoptosis; programmed cell death; zymogen; IAP;
D O I
10.1111/j.1699-0463.1999.tb01528.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Members of a family of cysteine proteases known as caspases orchestrate the intracellular biochemical events that enable animal cells to kill themselves by apoptosis. To counteract the apoptotic response to infection, some viruses have adapted and evolved proteins that specifically block caspases. More recently, it has been demonstrated that endogenous proteins belonging to the IAP family can regulate apoptosis by directly inactivating some of the caspases involved in initiating and executing programmed cell death.
引用
收藏
页码:73 / 79
页数:7
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