Vertical transmission of Kaposi's sarcoma-associated herpesvirus

被引：56
作者：
Mantina, H
Kankasa, C
Klaskala, W
Brayfield, B
Campbell, J
Du, QJ
Bhat, G
Kasolo, F
Mitchell, C
Wood, C
机构：
[1] Univ Nebraska, Nebraska Ctr Virol, Lincoln, NE 68588 USA
[2] Univ Zambia, Sch Med, Lusaka, Zambia
[3] Univ Miami, Sch Med, Miami, FL USA
来源：
INTERNATIONAL JOURNAL OF CANCER | 2001年 / 94卷 / 05期
关键词：
KSHV; HHV-8; vertical transmission;
D O I：
10.1002/ijc.1529
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Little is presently known about the specific routes of transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8). To investigate whether this agent might be transmitted vertically from mother to infant, we conducted a study on 89 KSHV seropositive mothers and their newborn infants. Thirteen mothers (14.6%) had KSHV DNA detected in their peripheral blood mononuclear cells (PBMC). Two of 89 samples drawn at birth from infants born to KSHV seropositive mothers had KSHV DNA detectable within their PBMC. These findings suggest that KSHV can be transmitted perinatally, but infrequently. Other routes of transmission such as horizontal transmission remain the most likely means of KSHV transmission. (C) 2001 Wiley-Liss, Inc.
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收藏
页码：749 / 752
页数：4
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