Solid-support synthesis of natural product-like compounds derived from D-(-)-ribose

被引：5
|
作者：
Messer, R
Pelle, X
Marzinzik, AL
Lehmann, H
Zimmermann, J
Häner, R
机构：
[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
[2] Novartis Inst BioMed Res, CH-4002 Basel, Switzerland
来源：
SYNLETT | 2005年 / 16期
关键词：
solid-phase synthesis; hetero Diels-Alder reactions; medicinal chemistry; combinatorial; furans;
D O I：
10.1055/s-2005-872684
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of natural product-like compounds on solid support is described. Starting from a readily accessible D-(-)ribose derivative, a tricyclic scaffold is prepared in five steps. After coupling onto solid Supports bearing different substituents (PAL resins), the scaffold can be further derivatised at two diversity points. Representative derivatives obtained by this diversity-oriented procedure are described.
引用
收藏
页码：2441 / 2444
页数：4
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