Copper-catalyzed Conjugate Additions of Alkylboranes to Aryl α,β-Unsaturated Ketones

被引：19

作者：

Ohmiya, Hirohisa ^{[1
]}

Shido, Yoshinori ^{[1
]}

Yoshida, Mika ^{[1
]}

Sawamura, Masaya ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Sci, Dept Chem, Sapporo, Hokkaido 0600810, Japan

来源：

CHEMISTRY LETTERS | 2011年 / 40卷 / 09期

关键词：

ARYLBORONIC ACIDS; DIORGANOZINC REAGENTS; CARBONYL-COMPOUNDS; GRIGNARD-REAGENTS; DIASTEREOSELECTIVE SYNTHESIS; ASYMMETRIC 1,4-ADDITION; ALLYLIC PHOSPHATES; ALDEHYDES; CONSTRUCTION; SUBSTITUTION;

D O I：

10.1246/cl.2011.928

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugate addition of alkylboron compounds (alkyl-9-BBN) to aryl alpha,beta-unsaturated ketones proceeded in the presence of a catalytic amount (10 mol %) of [(IPr)CuCl] and t-BuOK. The alkylboranes are available through alkene hydroboration, and thus the overall process represents a reductive conjugate addition of alkenes to enone derivatives. A variety of functional groups are tolerated in both the alkenes and the alpha,beta-unsaturated ketones.

引用

页码：928 / 930

页数：3

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