Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity

被引：471

作者：

Liu, Huiyu ^{[1
]}

Chen, Dong ^{[2
]}

Li, Linlin ^{[1
]}

Liu, Tianlong ^{[1
]}

Tan, Longfei ^{[1
,3
]}

Wu, Xiaoli ^{[1
]}

Tang, Fangqiong ^{[1
]}

机构：

[1] Chinese Acad Sci, Lab Controllable Preparat & Applicat Nanomat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

[2] Beijing Creat Nanophase Hitech Co Ltd, Beijing 100086, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 04期

基金：

中国国家自然科学基金;

关键词：

antitumor agents; chemotherapy; drug delivery; nanomedicine; photothermal therapy; ANTICANCER DRUGS; CANCER-CELLS; HYPERTHERMIA; NANOPARTICLES; ABLATION; AGENTS; ENHANCEMENT; FABRICATION; NANORODS; BLADDER;

D O I：

10.1002/anie.201002820

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magic bullets: A drug-loaded structure comprising a PEGylated (PEG=polyethylene glycol) gold nanoshell on silica nanorattle spheres (GSNs; see picture) combines remote-controlled photothermal therapy with chemotherapy. Tumor cells are killed with higher efficacy and less toxicity than the free drug. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：891 / 895

页数：5

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