A Microarray Study on the Expression of ANKRD49 in Lung Squamous Cell Carcinoma and Its Clinicopathologic Significance

被引：1

作者：

Li, Xin-yang ^{[1
]}

Qin, Ke-ru ^{[1
]}

Liu, Yue-hua ^{[1
]}

Pang, Min ^{[3
]}

Huo, Yun-kui ^{[2
]}

Yu, Bao-feng ^{[1
]}

Wang, Hai-long ^{[1
]}

机构：

[1] Shanxi Med Univ, Basic Med Sci Ctr, Sch Basic Med, Taiyuan, Shanxi, Peoples R China

[2] Shanxi Med Univ, Hosp 1, Dept Cardiothorac Surg, Taiyuan, Shanxi, Peoples R China

[3] Shanxi Med Univ, Hosp 1, Dept Pulm & Crit Care Med, Shanxi Prov Key Lab Resp Dis, Taiyuan, Shanxi, Peoples R China

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2022年 / 30卷 / 06期

关键词：

lung squamous cell carcinoma; ANKRD49; tissue microassay; biomarker; ANKYRIN REPEAT;

D O I：

10.1097/PAI.0000000000001039

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Lung squamous cell carcinoma (LUSC) is associated with poor clinical outcomes and identifying novel biomarkers that are involved in the progression of LUSC is important for prognosis and targeted treatment. Herein, ankyrin repeat domain 49 (ANKRD49) protein in LUSC versus paired noncancerous lung tissues was tested and its clinical significance was evaluated through chi(2) test, log-rank test, and Cox proportional hazards model. The results showed the ANKRD49 protein in LUSC was elevated and correlated with the tumor-node-metastasis stage, lymph node metastasis, distal metastasis, and differentiation. Patients with higher ANKRD49 had lower overall survival rate and higher ANKRD49 expression in lung tissues may be used as an independent prognostic marker for LUSC patients.

引用

页码：418 / 424

页数：7

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