Roles for Non-coding RNAs in Spatial Genome Organization

被引：14
作者：
Khosraviani, Negin [1 ]
Ostrowski, Lauren A. [1 ]
Mekhail, Karim [1 ,2 ]
机构：
[1] Univ Toronto, Fac Med, MaRS Ctr, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[2] Univ Toronto, Fac Med, Canada Res Chairs Program, Toronto, ON, Canada
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2019年 / 7卷
基金：
加拿大健康研究院;
关键词：
nuclear organization; non-coding RNA; DNA repeats; nucleolus; Cajal bodies (CBs); HETEROCHROMATIN FORMATION; EPIGENETIC REGULATION; X-INACTIVATION; NUCLEAR-BODIES; TRANSPOSABLE ELEMENTS; CENP-A; CHROMATIN ARCHITECTURE; SATELLITE TRANSCRIPTS; HISTONE ACETYLATION; IMMUNOGLOBULIN LOCI;
D O I：
10.3389/fcell.2019.00336
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Genetic loci are non-randomly arranged in the nucleus of the cell. This order, which is important to overall genome expression and stability, is maintained by a growing number of factors including the nuclear envelope, various genetic elements and dedicated protein complexes. Here, we review evidence supporting roles for non-coding RNAs (ncRNAs) in the regulation of spatial genome organization and its impact on gene expression and cell survival. Specifically, we discuss how ncRNAs from single-copy and repetitive DNA loci contribute to spatial genome organization by impacting perinuclear chromosome tethering, major nuclear compartments, chromatin looping, and various chromosomal structures. Overall, our analysis of the literature highlights central functions for ncRNAs and their transcription in the modulation of spatial genome organization with connections to human health and disease.
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页数：16
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