Mg(OCH3)2-mediated one-pot synthesis of α-aminophosphonate derivatives of cytosine under mild conditions

被引：1

作者：

Yuan, Jin-Wei ^{[1
]}

Li, Wei-Jie ^{[1
]}

机构：

[1] Henan Univ Technol, Sch Chem & Chem Engn, Academician Workstn Nat Med Chem Henan Prov, Zhengzhou 450001, Henan, Peoples R China

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2017年 / 72卷 / 08期

关键词：

alpha-aminophosphonate; cytosine; H-phosphite; Mg(OCH3)(2); one-pot; KABACHNIK-FIELDS REACTION; EFFICIENT SYNTHESIS; ACID-ANALOGS; WILD-TYPE; INHIBITORS; PYRIMIDINES; NUCLEOSIDES; DNA; PHOSPHONATES; ALDEHYDES;

D O I：

10.1515/znb-2017-0044

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient one-pot synthesis of alpha-aminophosphonates of cytosine with aldehydes, diisopropyl H-phosphite, and cytosine with the help of simple magnesium methanolate was discovered. alpha-Aminophosphonates of cytosine were obtained in good yields under mild conditions. The reaction tolerates both electron-donating and electron-withdrawing substituents of aromatic and aliphatic aldehydes.

引用

页码：563 / 571

页数：9

共 45 条

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