A microwave promoted and Lewis acid catalysed solventless approach to 4-azasteroids

被引：21

作者：

Borthakur, Moyurima ^{[1
]}

Boruah, Romesh C. ^{[1
]}

机构：

[1] NE Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India

来源：

STEROIDS | 2008年 / 73卷 / 06期

关键词：

4-azasteroids; urea; Lewis acid; microwave;

D O I：

10.1016/j.steroids.2008.01.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation of 3-oxo-4-azasteroid from A-nor-3,5-secosteroid-3-oic acid is described in a solventless condition catalysed by Lewis acid under microwave irradiation. We utilized urea as an environmentally benign source for the generation of ammonia for the aza cyclization reaction. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：637 / 641

页数：5

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