Epigenetics of Inflammatory Bowel Disease: Unraveling Pathogenic Events

被引:7
作者
Mateos, Beatriz [1 ]
Palanca-Ballester, Cora [2 ]
Saez-Gonzalez, Esteban [1 ]
Moret, Ines [1 ,3 ]
Lopez, Adrian [2 ]
Sandoval, Juan [2 ,4 ]
机构
[1] Hosp La Fe IIS La Fe, Inflammatory Bowel Dis Res Grp, Med Res Inst, Valencia, Spain
[2] Hosp La Fe IIS La Fe, Biomarkers & Precis Med Unit, Med Res Inst, Ave Fernando Abril Martorell 106, Valencia 46020, Spain
[3] Ctr Invest Biorned Red Area Temat Enfermedades He, Madrid, Spain
[4] Hosp La Fe HS La Fe, Med Res Inst, Epigen Core Facil, Valencia, Spain
关键词
epigenetics; inflammatory bowel diseases; diagnosis;
D O I
10.1093/crocol/otz017
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Epigenetics has emerged as a new and promising field in recent years. Because there exists a need to find new biomarkers and improve diagnosis, prognosis, and drug response for inflammatory bowel diseases, the research on epigenetic biomarkers for molecular diagnostics encourages the translation of this field from the bench to the clinical practice. In this review, we present an overview of the current knowledge and its potential applicability of this emerging field in inflammatory bowel diseases.
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页数:4
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共 18 条
  • [1] Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
    Arpon, Ana
    Milagro, Fermin I.
    Razquin, Cristina
    Corella, Dolores
    Estruch, Ramon
    Fito, Montserrat
    Marti, Amelia
    Martinez-Gonzalez, Miguel A.
    Ros, Emilio
    Salas-Salvado, Jordi
    Riezu-Boj, Jose-Ignacio
    Alfredo Martinez, J.
    [J]. NUTRIENTS, 2018, 10 (01)
  • [2] New Methylation Biomarker Panel for Early Diagnosis of Dysplasia or Cancer in High-Risk Inflammatory Bowel Disease Patients
    Azuara, Daniel
    Ausso, Susanna
    Rodriguez-Moranta, Francisco
    Guardiola, Jordi
    Sanjuan, Xavier
    Lobaton, Triana
    Boadas, Jaume
    Piqueras, Marta
    Monfort, David
    Guino, Elisabet
    Moreno, Victor
    Capella, Gabriel
    de Oca, Javier
    [J]. INFLAMMATORY BOWEL DISEASES, 2018, 24 (12) : 2555 - 2564
  • [3] Review article: changes in the epidemiology of inflammatory bowel disease-clues for aetiology
    Bernstein, C. N.
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2017, 46 (10) : 911 - 919
  • [4] Mucosal genome-wide methylation changes in inflammatory bowel disease
    Cooke, James
    Zhang, Hu
    Greger, Liliana
    Silva, Ana-Luisa
    Massey, Dunecan
    Dawson, Claire
    Metz, Andrew
    Ibrahim, Ashraf
    Parkes, Miles
    [J]. INFLAMMATORY BOWEL DISEASES, 2012, 18 (11) : 2128 - 2137
  • [5] Distinct Methylation of IFNG in the Gut
    Gonsky, Rivkah
    Deem, Richard L.
    Targan, Stephan R.
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2009, 29 (07) : 407 - 414
  • [6] A functional methylome map of ulcerative colitis
    Haesler, Robert
    Feng, Zhe
    Baeckdahl, Liselotte
    Spehlmann, Martina E.
    Franke, Andre
    Teschendorff, Andrew
    Rakyan, Vardhman K.
    Down, Thomas A.
    Wilson, Gareth A.
    Feber, Andrew
    Beck, Stephan
    Schreiber, Stefan
    Rosenstiel, Philip
    [J]. GENOME RESEARCH, 2012, 22 (11) : 2130 - 2137
  • [7] DNA Methylation Profile of Genes Involved in Inflammation and Autoimmunity in Inflammatory Bowel Disease
    Karatzas, Pantelis S.
    Mantzaris, Gerassimos J.
    Safioleas, Michael
    Gazouli, Maria
    [J]. MEDICINE, 2014, 93 (28) : e309
  • [8] Array-based identification of common DNA methylation alterations in ulcerative colitis
    Koizumi, Kei
    Alonso, Sergio
    Miyaki, Yuichiro
    Okada, Shinichiro
    Ogura, Hiroyuki
    Shiiya, Norihiko
    Konishi, Fumio
    Taya, Toshiki
    Perucho, Manuel
    Suzuki, Koichi
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 40 (04) : 983 - 994
  • [9] Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues
    Krautkramer, Kimberly A.
    Kreznar, Julia H.
    Romano, Kymberleigh A.
    Vivas, Eugenio I.
    Barrett-Wilt, Gregory A.
    Rabaglia, Mary E.
    Keller, Mark P.
    Attie, Alan D.
    Rey, Federico E.
    Denu, John M.
    [J]. MOLECULAR CELL, 2016, 64 (05) : 982 - 992
  • [10] Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
    Liu, Jimmy Z.
    van Sommeren, Suzanne
    Huang, Hailiang
    Ng, Siew C.
    Alberts, Rudi
    Takahashi, Atsushi
    Ripke, Stephan
    Lee, James C.
    Jostins, Luke
    Shah, Tejas
    Abedian, Shifteh
    Cheon, Jae Hee
    Cho, Judy
    Daryani, Naser E.
    Franke, Lude
    Fuyuno, Yuta
    Hart, Ailsa
    Juyal, Ramesh C.
    Juyal, Garima
    Kim, Won Ho
    Morris, Andrew P.
    Poustchi, Hossein
    Newman, William G.
    Midha, Vandana
    Orchard, Timothy R.
    Vahedi, Homayon
    Sood, Ajit
    Sung, Joseph J. Y.
    Malekzadeh, Reza
    Westra, Harm-Jan
    Yamazaki, Keiko
    Yang, Suk-Kyun
    Barrett, Jeffrey C.
    Franke, Andre
    Alizadeh, Behrooz Z.
    Parkes, Miles
    Thelma, B. K.
    Daly, Mark J.
    Kubo, Michiaki
    Anderson, Carl A.
    Weersma, Rinse K.
    [J]. NATURE GENETICS, 2015, 47 (09) : 979 - +