Structure-based and combinatorial search for new RNA-binding drugs

被引：52
作者：
Afshar, M
Prescott, CD
Varani, G
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[2] Ribotargets Ltd, Cambridge CB2 2JX, England
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0958-1669(99)80011-1
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The discovery by structure-based and combinatorial methods of new RNA-binding drugs presents great opportunities for pharmacological development against drug-resistant bacterial and viral pathogens. A handful of recent RNA structures and more numerous studies of the interaction of combinatorial libraries and oligomeric RNA-binding compounds are providing the foundation for effective RNA-targeted drug discovery programs.
引用
收藏
页码：59 / 63
页数：5
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