(E)-Selective Horner-Wadsworth-Emmons reaction of aldehydes with bis-(2,2,2-trifluoroethyl)phosphonoacetic acid

被引：19

作者：

Sano, S ^{[1
]}

Takemoto, Y ^{[1
]}

Nagao, Y ^{[1
]}

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

来源：

ARKIVOC | 2003年

关键词：

Horner-Wadsworth-Emmons reaction; olefination; magnesium; alpha; beta-unsaturated carboxylic acid; beta-unsaturated ester;

D O I：

10.3998/ark.5550190.0004.810

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective Horner-Wadsworth-Emmons reaction of aldehydes with bis-(2,2,2-trifluoroethyl)phosphonoacetic acid utilizing i-PrMgBr afforded (E)-alpha,beta-unsaturated carboxylic acids as the major products. bis-(2,2,2-Trifluoroethyl)phosphonoacetic acid was prepared by enzymatic hydrolysis of the corresponding methyl ester with porcine liver esterase.

引用

页码：93 / 101

页数：9

共 32 条

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