(E)-Selective Horner-Wadsworth-Emmons reaction of aldehydes with bis-(2,2,2-trifluoroethyl)phosphonoacetic acid

被引：19
|
作者：
Sano, S [1 ]
Takemoto, Y [1 ]
Nagao, Y [1 ]
机构：
[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan
来源：
ARKIVOC | 2003年
关键词：
Horner-Wadsworth-Emmons reaction; olefination; magnesium; alpha; beta-unsaturated carboxylic acid; beta-unsaturated ester;
D O I：
10.3998/ark.5550190.0004.810
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The stereoselective Horner-Wadsworth-Emmons reaction of aldehydes with bis-(2,2,2-trifluoroethyl)phosphonoacetic acid utilizing i-PrMgBr afforded (E)-alpha,beta-unsaturated carboxylic acids as the major products. bis-(2,2,2-Trifluoroethyl)phosphonoacetic acid was prepared by enzymatic hydrolysis of the corresponding methyl ester with porcine liver esterase.
引用
收藏
页码：93 / 101
页数：9
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