New method for routine production of L-[methyl-11C]methionine:: in loop synthesis

被引：25

作者：

Gomez, Vanessa ^{[1
,2
]}

Gispert, Juan Domingo ^{[1
,2
]}

Amador, Victor ^{[1
]}

Llop, Jordi ^{[1
,2
]}

机构：

[1] Inst Alta Tecnol PSBB Fundacio Privada, Barcelona, Spain

[2] CIBER BBN, Barcelona, Spain

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2008年 / 51卷 / 1-2期

关键词：

methylation; loop; methionine;

D O I：

10.1002/jlcr.1483

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A fast, clean and reproducible method for the manufacture of the radiotracer L-[methyl-(11)C]methionine is reported. The reaction at room temperature of the non-radioactive precursor L-homocysteine (1 mg solution in ethanol/water 50/50) with [(11)C]CH(3)I in an HPLC loop led to the formation of the desired radiotracer with a high radiochemical yield (38.4 +/- 4.1% end of synthesis) in a short production time (12 min). Radiochemical purity of the final radiotracer was 99.9 +/- 0.05%. Specific activities in the range 11-45 GBq/mu mol were obtained. The presence of the undesired enantiomer (D-[methyl-(11)C)methionine) was not detected in any of the cases.

引用

页码：83 / 86

页数：4

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