AID is a poor prognostic marker of high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

被引：7

作者：

Miyaoka, Masashi ^{[1
]}

Kikuti, Yara Yukie ^{[1
]}

Carreras, Joaquim ^{[1
]}

Itou, Atsushi ^{[1
]}

Ikoma, Haruka ^{[1
]}

Tomita, Sakura ^{[1
]}

Shiraiwa, Sawako ^{[2
]}

Ando, Kiyoshi ^{[2
]}

Nakamura, Naoya ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Pathol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan

[2] Tokai Univ, Sch Med, Dept Hematol Oncol, Isehara, Kanagawa, Japan

来源：

PATHOLOGY INTERNATIONAL | 2022年 / 72卷 / 01期

基金：

日本学术振兴会;

关键词：

AICDA; AID; gene expression profile; high-grade B-cell lymphoma with MYC and BCL2 and; or BCL6 rearrangements; immunohistochemistry; INDUCED CYTIDINE DEAMINASE; RITUXIMAB PLUS CYCLOPHOSPHAMIDE; CHRONIC LYMPHOCYTIC-LEUKEMIA; DOUBLE-HIT LYMPHOMA; EXPRESSION; VINCRISTINE; DOXORUBICIN; MUTATIONS; SURVIVAL; IMPACT;

D O I：

10.1111/pin.13182

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Diffuse large B-cell lymphoma with MYC rearrangement is defined as double/triple-hit lymphoma (DHL/THL) or single-hit lymphoma (SHL) by the inclusion of the BCL2 and BCL6 rearrangements status. DHL/THL is called as "high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements" in the World Health Organization 2017 Classification of Tumors of Hematopoietic and Lymphoid Tissues. To find a prognostic biomarker of DHL/THL, we firstly examined 19 cases (molecular analysis series;10 cases of DHL/THL and 9 cases of SHL) with gene expression profile analysis. The gene expression profile analysis showed that the high expression of AICDA was associated with an adverse prognosis in DHL/THL, but not in SHL. Then, we evaluated immunohistochemical expression of AID, the protein product of AICDA, in 50 cases (molecular analysis series of 19 cases and additional immunohistochemistry series of 31 cases; 12 cases of DHL/THL and 19 cases of SHL) and confirmed that its expression was also associated with an adverse prognosis in DHL/THL. Therefore, AICDA and AID can be a predictor of an adverse clinical outcome in DHL/THL and immunohistochemistry of AID is useful to find DHL/THL-adverse prognosis group.

引用

页码：35 / 42

页数：8

共 38 条

[1] Prognostic impact of activation-induced cytidine deaminase expression for patients with diffuse large B-cell lymphoma [J].

Arima, Hiroshi ;

Fujimoto, Masakazu ;

Nishikori, Momoko ;

Kitano, Toshiyuki ;

Kishimoto, Wataru ;

Hishizawa, Masakatsu ;

Kondo, Tadakazu ;

Yamashita, Kouhei ;

Hirata, Masahiro ;

Haga, Hironori ;

Takaori-Kondo, Akifumi .

LEUKEMIA & LYMPHOMA, 2018, 59 (09) :2085-2095

[2] Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma [J].

Aukema, Sietse M. ;

Kreuz, Markus ;

Kohler, Christian W. ;

Rosolowski, Maciej ;

Hasenclever, Dirk ;

Hummel, Michael ;

Kueppers, Ralf ;

Lenze, Dido ;

Ott, German ;

Pott, Christiane ;

Richter, Julia ;

Rosenwald, Andreas ;

Szczepanowski, Monika ;

Schwaenen, Carsten ;

Stein, Harald ;

Trautmann, Heiko ;

Wessendorf, Swen ;

Truemper, Lorenz ;

Loeffler, Markus ;

Spang, Rainer ;

Kluin, Philip M. ;

Klapper, Wolfram ;

Siebert, Reiner .

HAEMATOLOGICA, 2014, 99 (04) :726-735

[3] UniProt: a worldwide hub of protein knowledge [J].

Bateman, Alex ;

Martin, Maria-Jesus ;

Orchard, Sandra ;

Magrane, Michele ;

Alpi, Emanuele ;

Bely, Benoit ;

Bingley, Mark ;

Britto, Ramona ;

Bursteinas, Borisas ;

Busiello, Gianluca ;

Bye-A-Jee, Hema ;

Da Silva, Alan ;

De Giorgi, Maurizio ;

Dogan, Tunca ;

Castro, Leyla Garcia ;

Garmiri, Penelope ;

Georghiou, George ;

Gonzales, Daniel ;

Gonzales, Leonardo ;

Hatton-Ellis, Emma ;

Ignatchenko, Alexandr ;

Ishtiaq, Rizwan ;

Jokinen, Petteri ;

Joshi, Vishal ;

Jyothi, Dushyanth ;

Lopez, Rodrigo ;

Luo, Jie ;

Lussi, Yvonne ;

MacDougall, Alistair ;

Madeira, Fabio ;

Mahmoudy, Mahdi ;

Menchi, Manuela ;

Nightingale, Andrew ;

Onwubiko, Joseph ;

Palka, Barbara ;

Pichler, Klemens ;

Pundir, Sangya ;

Qi, Guoying ;

Raj, Shriya ;

Renaux, Alexandre ;

Lopez, Milagros Rodriguez ;

Saidi, Rabie ;

Sawford, Tony ;

Shypitsyna, Aleksandra ;

Speretta, Elena ;

Turner, Edward ;

Tyagi, Nidhi ;

Vasudev, Preethi ;

Volynkin, Vladimir ;

Wardell, Tony .

NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) :D506-D515

[4] The prognosis of MYC translocation positive diffuse large B-cell lymphoma depends on the second hit [J].

Clipson, Alexandra ;

Barrans, Sharon ;

Zeng, Naiyan ;

Crouch, Simon ;

Grigoropoulos, Nicholas F. ;

Liu, Hongxiang ;

Kocialkowski, Sylvia ;

Wang, Ming ;

Huang, Yuanxue ;

Worrillow, Lisa ;

Goodlad, John ;

Buxton, Jenny ;

Neat, Michael ;

Fields, Paul ;

Wilkins, Bridget ;

Grant, John W. ;

Wright, Penny ;

El-Daly, Hesham ;

Follows, George A. ;

Roman, Eve ;

Watkins, A. James ;

Johnson, Peter W. M. ;

Jack, Andrew ;

Du, Ming-Qing .

JOURNAL OF PATHOLOGY CLINICAL RESEARCH, 2015, 1 (03) :125-133

[5] MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study [J].

Copie-Bergman, Christiane ;

Cuilliere-Dartigues, Peggy ;

Baia, Maryse ;

Briere, Josette ;

Delarue, Richard ;

Canioni, Danielle ;

Salles, Gilles ;

Parrens, Marie ;

Belhadj, Karim ;

Fabiani, Bettina ;

Recher, Christian ;

Petrella, Tony ;

Ketterer, Nicolas ;

Peyrade, Frederic ;

Haioun, Corinne ;

Nagel, Inge ;

Siebert, Reiner ;

Jardin, Fabrice ;

Leroy, Karen ;

Jais, Jean-Philippe ;

Tilly, Helve ;

Molina, Thierry Jo ;

Gaulard, Philippe .

BLOOD, 2015, 126 (22) :2466-2474

[6] Analysis of IgVH gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery [J].

Degan, M ;

Bomben, R ;

Dal Bo, M ;

Zucchetto, A ;

Nanni, P ;

Rupolo, M ;

Steffan, A ;

Attadia, V ;

Ballerini, PF ;

Damiani, D ;

Pucillo, C ;

Del Poeta, G ;

Colombatti, A ;

Gattei, V .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 126 (01) :29-42

[7] Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma [J].

Ennishi, Daisuke ;

Jiang, Aixiang ;

Boyle, Merrill ;

Collinge, Brett ;

Grande, Bruno M. ;

Ben-Neriah, Susana ;

Rushton, Christopher ;

Tang, Jeffrey ;

Thomas, Nicole ;

Slack, Graham W. ;

Farinha, Pedro ;

Takata, Katsuyoshi ;

Miyata-Takata, Tomoko ;

Craig, Jeffrey ;

Mottok, Anja ;

Meissner, Barbara ;

Saberi, Saeed ;

Bashashati, Ali ;

Villa, Diego ;

Savage, Kerry J. ;

Sehn, Laurie H. ;

Kridel, Robert ;

Mungall, Andrew J. ;

Marra, Marco A. ;

Shah, Sohrab P. ;

Steidl, Christian ;

Connors, Joseph M. ;

Gascoyne, Randy D. ;

Morin, Ryan D. ;

Scott, David W. .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (03) :190-+

[8] Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin-specific clinical impact [J].

Ennishi, Daisuke ;

Mottok, Anja ;

Ben-Neriah, Susana ;

Shulha, Hennady P. ;

Farinha, Pedro ;

Chan, Fong Chun ;

Meissner, Barbara ;

Boyle, Merrill ;

Hother, Christoffer ;

Kridel, Robert ;

Lai, Daniel ;

Saberi, Saeed ;

Bashashati, Ali ;

Shah, Sohrab P. ;

Morin, Ryan D. ;

Marra, Marco A. ;

Savage, Kerry J. ;

Sehn, Laurie H. ;

Steidl, Christian ;

Connors, Joseph M. ;

Gascoyne, Randy D. ;

Scott, David W. .

BLOOD, 2017, 129 (20) :2760-2770

[9] Targeted next generation sequencing reveals high mutation frequency of CREBBP, BCL2 and KMT2D in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements [J].

Evrard, Solene M. ;

Pericart, Sarah ;

Grand, David ;

Amara, Nadia ;

Escudie, Frederic ;

Gilhodes, Julia ;

Bories, Pierre ;

Traverse-Glehen, Alexandra ;

Dubois, Romain ;

Brousset, Pierre ;

Parrens, Marie ;

Laurent, Camille .

HAEMATOLOGICA, 2019, 104 (04) :E154-E157

[10] Immunohistochemical Double-Hit Score Is a Strong Predictor of Outcome in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone [J].

Green, Tina Marie ;

Young, Ken H. ;

Visco, Carlo ;

Xu-Monette, Zijun Y. ;

Orazi, Attilio ;

Go, Ronald S. ;

Nielsen, Ole ;

Gadeberg, Ole V. ;

Mourits-Andersen, Torben ;

Frederiksen, Mikael ;

Pedersen, Lars Moller ;

Moller, Michael Boe .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (28) :3460-3467

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