Evolving classification of rhabdomyosarcoma

被引：85

作者：

Agaram, Narasimhan P. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10065 USA

来源：

HISTOPATHOLOGY | 2022年 / 80卷 / 01期

关键词：

alveolar; embryonal; FOXO1; MYOD1; pleomorphic; rhabdomyosarcoma; spindle cell; sclerosing; SPINDLE-CELL RHABDOMYOSARCOMA; EMBRYONAL RHABDOMYOSARCOMA; IMMUNOHISTOCHEMICAL ANALYSIS; SCLEROSING RHABDOMYOSARCOMA; CHILDHOOD RHABDOMYOSARCOMA; CHROMOSOMAL TRANSLOCATION; ADULTS; COMMON; GENE; SARCOMAS;

D O I：

10.1111/his.14449

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rhabdomyosarcomas comprise the single largest category of soft tissue sarcomas in children and adolescents in the United States, occurring in 4.5 million people aged below 20 years. Based on the clinicopathological features and genetic abnormalities identified, rhabdomyosarcomas are classified into embryonal, alveolar, spindle cell/sclerosing and pleomorphic subtypes. Each subtype shows distinctive morphology and has characteristic genetic abnormalities. This review discusses the evolution of the classification of rhabdomyosarcoma to the present day, together with a discussion of key histomorphological and genetic features of each subtype and the diagnostic approach to these tumours.

引用

页码：98 / 108

页数：11

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