Pulmonary hypertension in chronic heart failure: definitions, advances, and unanswered issues

被引：23

作者：

Berthelot, Emmanuelle ^{[1
,2
]}

Bauer, Fabrice ^{[3
]}

Eicher, Jean-Christophe ^{[4
]}

Flecher, Erwan ^{[5
,6
]}

Gellen, Barnabas ^{[7
]}

Guihaire, Julien ^{[8
]}

Guijarro, Damien ^{[9
]}

Roul, Gerald ^{[10
]}

Salvat, Muriel ^{[11
]}

Tribouilloy, Christophe ^{[12
,13
]}

Zores, Florian ^{[14
]}

Lamblin, Nicolas ^{[15
]}

de Groote, Pascal ^{[16
,17
]}

Damy, Thibaud ^{[18
]}

机构：

[1] Univ Paris Sud, Le Kremlin Bicetre, France

[2] Hop Bicetre, AP HP, Pole Thorax, Serv Cardiol, 78 Rue Gen Leclerc, F-94275 Le Kremlin Bicetre, France

[3] Rouen Univ Hosp, Dept Cardiol, INSERM, U1096, F-76031 Rouen, France

[4] Dijon Univ Hosp, Dept Cardiol, 14 Rue Paul Gaffarel, F-21000 Dijon, France

[5] Rennes Univ Hosp, Dept Thorac & Cardiovasc Surg, Rennes, France

[6] Univ Rennes 1, Res Unit, INSERM, U1099, Rennes, France

[7] Polyclin Poitiers, ELSAN, 1 Rue Providence, F-86035 Poitiers, France

[8] Univ Paris Sud, Marie Lannelongue Hosp 1, Cardiothorac Surg, 133 Ave Resistance, F-92350 Le Plessis Robinson, France

[9] Grp Hosp Mutualiste Grenoble, Inst Cardiovasc, Grenoble, France

[10] Univ Strasbourg, Fac Med, 4 Rue Kirschleger, F-67085 Strasbourg, France

[11] CHU Grenoble Alpes, Pole Thorax & Vaisseaux, La Tronche, France

[12] Amiens Univ Hosp, Dept Cardiol, Amiens, France

[13] Jules Verne Univ Picardie, INSERM, U1088, Amiens, France

[14] Grp Med Specialise, Strasbourg, France

[15] Univ Lille, INSERM, U1167, Inst Pasteur Lille,Serv CHU Lille, F-59000 Lille, France

[16] CHU Lille, Serv Cardiol, F-59000 Lille, France

[17] Inst Pasteur, INSERM, U1167, F-59000 Lille, France

[18] Henry Mondor Hosp, UPEC, Dept Cardiol,GRC Amyloid Res Inst, INSERM,U955,Heart Failure & Amyloidosis Unit, 51 Ave Marechal de Lattre de Tassigny, F-94000 Creteil, France

来源：

ESC HEART FAILURE | 2018年 / 5卷 / 05期

关键词：

Heart failure; Pulmonary hypertension; Pathophysiology; Classification; Diagnosis; Treatment; Heart transplantation; PRESERVED EJECTION FRACTION; RIGHT-VENTRICULAR FUNCTION; ARTERY PRESSURE; PROGNOSTIC VALUE; SYSTOLIC FUNCTION; CAPILLARY; EXERCISE; GUIDELINES; MORTALITY; GRADIENT;

D O I：

10.1002/ehf2.12316

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary hypertension (PH) is a common and severe complication of heart failure (HF). Consequently, HF is the leading cause of PH. For many years, specialists have attempted to better understand the pathophysiology of PH in HF, to define its prevalence and its impact on prognosis in order to improve the therapeutic management of these patients. Nowadays, despite the recent guidelines published on the subject, several points remain unclear or debated, and until now, no study has demonstrated the efficacy of any treatment. The aim of this review is to report the evolution of the concepts on post-capillary PH (diagnosis, prevalence, prognosis, and therapeutics). The main issues are raised, focusing especially on the link between structural alterations and haemodynamic abnormalities, to discuss the possible reasons for treatment failures and future potential targets.

引用

页码：755 / 763

页数：9

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