New approaches and procedures for cancer treatment: Current perspectives

被引:917
作者
Debela, Dejene Tolossa [1 ]
Muzazu, Seke G. Y. [1 ,2 ]
Heraro, Kidist Digamo [1 ,3 ]
Ndalama, Maureen Tayamika [1 ]
Mesele, Betelhiem Woldemedhin [1 ,4 ]
Haile, Dagimawi Chilot [1 ,5 ]
Kitui, Sophia Khalayi [1 ]
Manyazewal, Tsegahun [1 ]
机构
[1] Addis Ababa Univ, Ctr Innovat Drug Dev & Therapeut Trials Africa CD, Coll Hlth Sci, POB 9086, Addis Ababa, Ethiopia
[2] Ctr Infect Dis Res Zambia CIDRZ, Enter Dis & Vaccines Res Unit, Lusaka, Zambia
[3] Wachemo Univ, Hossana, Ethiopia
[4] Kotebe Metropolitan Univ, Addis Ababa, Ethiopia
[5] Univ Gondar, Gondar, Ethiopia
关键词
Cancer; treatment; stem cell; targeted drugs; ablation; natural antioxidants; gene therapy; TUMOR MICROENVIRONMENT; OXIDATIVE STRESS; DRUG-DELIVERY; STEM-CELLS; THERAPY; ANTICANCER; MECHANISMS; QUERCETIN; ABLATION; SYSTEMS;
D O I
10.1177/20503121211034366
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cancer is a global health problem responsible for one in six deaths worldwide. Treating cancer has been a highly complex process. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have been in use, while significant advances are being made in recent times, including stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemodynamic therapy, sonodynamic therapy, and ferroptosis-based therapy. Current methods in oncology focus on the development of safe and efficient cancer nanomedicines. Stem cell therapy has brought promising efficacy in regenerating and repairing diseased or damaged tissues by targeting both primary and metastatic cancer foci, and nanoparticles brought new diagnostic and therapeutic options. Targeted therapy possessed breakthrough potential inhibiting the growth and spread of specific cancer cells, causing less damage to healthy cells. Ablation therapy has emerged as a minimally invasive procedure that burns or freezes cancers without the need for open surgery. Natural antioxidants demonstrated potential tracking down free radicals and neutralizing their harmful effects thereby treating or preventing cancer. Several new technologies are currently under research in clinical trials, and some of them have already been approved. This review presented an update on recent advances and breakthroughs in cancer therapies.
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页数:10
相关论文
共 87 条
[1]  
Abbas Z., 2018, Neoplasm, P139, DOI [10.5772/intechopen.76558, DOI 10.5772/INTECHOPEN.76558]
[2]   Monoclonal antibody therapy of cancer [J].
Adams, GP ;
Weiner, LM .
NATURE BIOTECHNOLOGY, 2005, 23 (09) :1147-1157
[3]   Modulation of the Tumor Microenvironment for Cancer Treatment: A Biomaterials Approach [J].
Adjei, Isaac M. ;
Blanka, Sharma .
JOURNAL OF FUNCTIONAL BIOMATERIALS, 2015, 6 (01) :81-103
[4]   p53 Mutations and survival in stage I non-small-cell lung cancer: Results of a prospective study [J].
Ahrendt, SA ;
Hu, YC ;
Buta, M ;
McDermott, MP ;
Benoit, N ;
Yang, SC ;
Wu, L ;
Sidransky, D .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (13) :961-970
[5]  
American Cancer Society, 2019, ABL LIV CANC
[6]   Exploring the pH Sensitivity of Poly(allylamine) Phosphate Supramolecular Nanocarriers for Intracellular siRNA Delivery [J].
Andreozzi, Patrizia ;
Diamanti, Eleftheria ;
Py-Daniel, Karen Rapp ;
Caceres-Velez, Paolin Rocio ;
Martinelli, Chiara ;
Politakos, Nikolaos ;
Escobar, Ane ;
Muzi-Falconi, Marco ;
Azevedo, Ricardo ;
Moya, Sergio E. .
ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (44) :38242-38254
[7]  
Arruebo Manuel, 2011, Cancers (Basel), V3, P3279, DOI 10.3390/cancers3033279
[8]  
Bailey KM, 2012, ADV PHARMACOL, V65, P63, DOI 10.1016/B978-0-12-397927-8.00004-X
[9]   Cancer stem cells revisited [J].
Batlle, Eduard ;
Clevers, Hans .
NATURE MEDICINE, 2017, 23 (10) :1124-1134
[10]   Natural products for human health: an historical overview of the drug discovery approaches [J].
Bernardini, S. ;
Tiezzi, A. ;
Masci, V. Laghezza ;
Ovidi, E. .
NATURAL PRODUCT RESEARCH, 2018, 32 (16) :1926-1950