Virus-based nanocarriers for drug delivery

被引：347

作者：

Ma, Yujie ^{[1
,2
]}

Nolte, Roeland J. M. ^{[1
]}

Cornelissen, Jeroen J. L. M. ^{[2
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands

[2] Univ Twente, MESA Inst Nanotechnol, Grp Biomol Nanotechnol, NL-7500 AE Enschede, Netherlands

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2012年 / 64卷 / 09期

关键词：

Virus; Virus-like particle (VLP); Drug delivery; Bioconjugation; Supramolecular chemistry; Targeting; YELLOW MOSAIC-VIRUS; IN-VITRO; CHEMICAL-MODIFICATION; PROTEIN CAGES; COAT PROTEIN; MEDIATED DELIVERY; TARGETED DELIVERY; PLANT-VIRUS; NANOPARTICLES; PARTICLES;

D O I：

10.1016/j.addr.2012.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity. bio-distribution and immunology of these materials are envisaged to boost their application potentials. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：811 / 825

页数：15

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