Bile acid-activated cell signalling cascades and the regulation of cholesterol 7α-hydroxylase in primary rat hepatocytes in culture

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作者
Hylemon, PB [1 ]
Gupta, S [1 ]
Studer, E [1 ]
Dent, P [1 ]
Vlahcevic, ZR [1 ]
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[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Microbiol & Immunol, Richmond, VA 23298 USA
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BIOLOGY OF BILE ACIDS IN HEALTH AND DISEASE | 2001年 / 120卷
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R57 [消化系及腹部疾病];
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页码:59 / 70
页数:12
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共 23 条
[1]   Farnesoid X receptor responds to bile acids and represses cholesterol 7α-hydroxylase gene (CYP7A1) transcription [J].
Chiang, JYL ;
Kimmel, R ;
Weinberger, C ;
Stroup, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (15) :10918-10924
[2]   HEPATIC GENE-THERAPY - EFFICIENT GENE DELIVERY AND EXPRESSION IN PRIMARY HEPATOCYTES UTILIZING A CONJUGATED ADENOVIRUS-DNA COMPLEX [J].
CRISTIANO, RJ ;
SMITH, LC ;
KAY, MA ;
BRINKLEY, BR ;
WOO, SLC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11548-11552
[3]   α1-fetoprotein transcription factor is required for the expression of sterol 12α-hydroxylase, the specific enzyme for cholic acid synthesis -: Potential role in the bile acid-mediated regulation of gene transcription [J].
del Castillo-Olivares, A ;
Gil, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17793-17799
[4]  
del Castillo-Olivares A, 2000, NUCLEIC ACIDS RES, V28, P3587
[5]   Regulation of hepatic neutral cholesteryl ester hydrolase by hormones and changes in cholesterol flux [J].
Ghosh, S ;
Natarajan, R ;
Pandak, WM ;
Hylemon, PB ;
Grogan, WM .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 274 (04) :G662-G668
[6]   A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis [J].
Goodwin, B ;
Jones, SA ;
Price, RR ;
Watson, MA ;
McKee, DD ;
Moore, LB ;
Galardi, C ;
Wilson, JG ;
Lewis, MC ;
Roth, ME ;
Maloney, PR ;
Willson, TM ;
Kliewer, SA .
MOLECULAR CELL, 2000, 6 (03) :517-526
[7]   Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene -: Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer [J].
Grober, J ;
Zaghini, I ;
Fujii, H ;
Jones, SA ;
Kliewer, SA ;
Willson, TM ;
Ono, T ;
Besnard, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) :29749-29754
[8]   Regulation of multidrug resistance 2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes [J].
Gupta, S ;
Stravitz, RT ;
Pandak, WM ;
Müller, M ;
Vlahcevic, ZR ;
Hylemon, PB .
HEPATOLOGY, 2000, 32 (02) :341-347
[9]  
HYLEMON PB, 1992, J BIOL CHEM, V267, P16866
[10]   Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors [J].
Lu, TT ;
Makishima, M ;
Repa, JJ ;
Schoonjans, K ;
Kerr, TA ;
Auwerx, J ;
Mangelsdorf, DJ .
MOLECULAR CELL, 2000, 6 (03) :507-515