Temporomandibular-evoked jaw muscle reflex: role of brain stem NMDA and non-NMDA receptors

被引：38

作者：

Cairns, BE ^{[1
]}

Sessle, BJ ^{[1
]}

Hu, JW ^{[1
]}

机构：

[1] Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada

来源：

NEUROREPORT | 2001年 / 12卷 / 09期

关键词：

brain stern; excitatory amino acid receptors; medullary dorsal horn; trigeminal;

D O I：

10.1097/00001756-200107030-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated the possible involvement of brain stem excitatory amino acid receptor mechanisms and the trigeminal subnucleus caudalis (Vc) in temporomandibular joint (TMJ)evoked reflex jaw muscle activity. Glutamate injected into the TMJ of anesthetized rats reflexly evoked activity in the jaw muscles. Application of lidocaine, but not saline, to the surface of the caudal brainstem overlying Vc significantly suppressed TMJ-evoked jaw muscle activity, while application of NMDA or non-NMDA receptor antagonists also significantly attenuated jaw muscle activity. These results provide evidence that Vc is a critical relay in the TMJ-evoked reflex activation of the jaw muscles, and that both NMDA and non-NMDA receptor mechanisms may contribute to these effects. NeuroReport 12: 1875-1878 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：1875 / 1878

页数：4

共 21 条

[1] Excitatory amino release within spinal trigeminal nucleus after mustard oil injection into the temporomandibular joint region of the rat [J].