The target of rapamycin (TOR) proteins

被引：498
作者：
Raught, B
Gingras, AC
Sonenberg, N
机构：
[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Ctr Canc, Montreal, PQ H3G 1Y6, Canada
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 13期
关键词：
D O I：
10.1073/pnas.121145898
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity. The TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis. (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation.
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收藏
页码：7037 / 7044
页数：8
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