Monitoring the response to pharmacologic therapy in patients with stable chronic heart failure: Is BNP or NT-proBNP a useful assessment tool?

被引：14

作者：

Balion, Cynthia M. ^{[2
,3
]}

McKelvie, Robert S. ^{[4
]}

Reichert, Sonja ^{[5
]}

Santaguida, Pasqualina ^{[1
]}

Booker, Lynda

Worster, Andrew ^{[6
]}

Raina, Parminder

McQueen, Matthew J. ^{[2
,3
]}

Hill, Stephen ^{[2
,3
]}

机构：

[1] McMaster Univ, McMaster Evidence Based Practice Ctr, Dept Clin Epidemiol & Biostat, Hamilton, ON L8N 1E9, Canada

[2] Hamilton Reg Lab Med Program, Hamilton, ON, Canada

[3] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8S 4L8, Canada

[4] McMaster Univ, Dept Med, Div Cardiol, Hamilton, ON L8S 4L8, Canada

[5] Univ British Columbia, Dept Med, Div Gen Internal Med, Vancouver, BC V5Z 1M9, Canada

[6] McMaster Univ, Dept Med, Div Emergency Med, Hamilton, ON L8S 4L8, Canada

来源：

CLINICAL BIOCHEMISTRY | 2008年 / 41卷 / 4-5期

关键词：

therapy; monitoring; drugs; BNP; NT-proBNP; heart failure; systematic review;

D O I：

10.1016/j.clinbiochem.2007.10.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: B-type natriuretic peptides are biomarkers of heart failure (HF) that can decrease following treatment. We sought to determine whether B-type natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) concentration changes occurred in parallel to changes in other measures of heart failure following treatment. Methods: We conducted a systematic review of the literature for studies that assessed B-type natriuretic peptide measurements in treatment monitoring of patients with stable chronic heart failure. Selected studies had to include at least three consecutive measurements of BNP or NT-proBNP. Results: Of 4338 citations screened, only 12 met all of the selection criteria. The selected studies included populations with a wide range of heart failure severity and therapy. BNP and NT-proBNP decreased following treatment in nine studies and was associated with improvement in clinical measures of HF. Conclusions: There was limited data to support using BNP or NT-proBNP to monitor therapy in patients with HF. (C) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：266 / 276

页数：11

共 36 条

[1] Methods of assessing the functional status of patients with left ventricular systolic dysfunction in interventional studies: Can brain natriuretic peptide measurement be used as surrogate for the traditional methods? [J].

Abdulla, J ;

Kober, L ;

Torp-Pedersen, C .

CARDIOVASCULAR DRUGS AND THERAPY, 2004, 18 (03) :219-224

[2] Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT) [J].

Anand, IS ;

Fisher, LD ;

Chiang, YT ;

Latini, R ;

Masson, S ;

Maggioni, AP ;

Glazer, RD ;

Tognoni, G ;

Cohn, JN .

CIRCULATION, 2003, 107 (09) :1278-1283

[3] ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult - Summary article [J].

不详 .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 46 (06) :1116-1143

[4] Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation, and use of biomarkers [J].

Arnold, J. Malcolm O. ;

Howlett, Jonathan G. ;

Dorian, Paul ;

Ducharme, Anique ;

Giannetti, Nadia ;

Haddad, Haissam ;

Heckman, George A. ;

Ignaszewski, Andrew ;

Isaac, Debra ;

Jong, Philip ;

Liu, Peter ;

Mann, Elizabeth ;

McKelvie, Robert S. ;

Moe, Gordon W. ;

Parker, John D. ;

Svendsen, Anna M. ;

Tsuyuki, Ross T. ;

O'Halloran, Kelly ;

Ross, Heather J. ;

Rao, Vivek ;

Sequeira, Errol J. ;

White, Michel .

CANADIAN JOURNAL OF CARDIOLOGY, 2007, 23 (01) :21-45

[5]

BALION C, 2006, TESTING BNP NTPROBNP

[6] Morbidity, mortality, physiologic and functional parameters in elderly and non-elderly patients in the Valsartan Heart Failure Trial (Val-HeFT) [J].

Baruch, L ;

Glazer, RD ;

Aknay, N ;

Vanhaecke, J ;

Heywood, JT ;

Anand, I ;

Phil, D ;

Krum, H ;

Hester, A ;

Cohn, JN .

AMERICAN HEART JOURNAL, 2004, 148 (06) :951-957

[7]

BOSSUYT LIP, 1998, DIAGNOSTIC TEST APPR

[8] Management of elderly patients with congestive heart failure - Design of the trial of intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME-CHF) [J].

Brunner-La Rocca, Hans Peter ;

Buser, Peter Theo ;

Schindler, Ruth ;

Bernheim, Alain ;

Rickenbacher, Peter ;

Pfisterer, Matthias .

AMERICAN HEART JOURNAL, 2006, 151 (05) :949-955

[9] Within-patient comparison of effects of different dosages of enalapril on functional capacity and neurohormone levels in patients with chronic heart failure [J].

Brunner-La Rocca, HP ;

Weilenmann, D ;

Kiowski, W ;

Maly, FE ;

Candinas, R ;

Follath, F .

AMERICAN HEART JOURNAL, 1999, 138 (04) :654-662

[10] How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review [J].

Doust, JA ;

Pietrzak, E ;

Dobson, A ;

Glasziou, PP .

BRITISH MEDICAL JOURNAL, 2005, 330 (7492) :625-627

← 1 2 3 4 →