Lipid-Regulating Effect of Traditional Chinese Medicine: Mechanisms of Actions

被引：25
作者：
Bei, Wei-Jian [1 ]
Guo, Jiao [1 ]
Wu, Hai-Yun [2 ]
Cao, Yang [1 ]
机构：
[1] Guangzhou Univ Chinese Med, Guangdong Pharmaceut Univ,Key Unit Modulating Liv, Guangzhou Higher Educ Mega Ctr,State Adm Tradit C, Inst Chinese Med Sci,Guangdong TCM Key Lab Metab, Guangzhou 510006, Guangdong, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Inst Geriatr Cardiol, Beijing 100853, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷
基金：
美国国家科学基金会;
关键词：
NIEMANN-PICK C1-LIKE-1; GENE-EXPRESSION; HEPATIC LIPASE; HYPOLIPIDEMIC MECHANISMS; CHOLESTEROL-METABOLISM; LIPOPROTEIN-LIPASE; SERUM-CHOLESTEROL; NATURAL-PRODUCT; PPAR-ALPHA; BILE-ACID;
D O I：
10.1155/2012/970635
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Traditional Chinese medicine (TCM) has been increasingly used for the treatment of dyslipidemia and cardiovascular disease. Recently, much progress has been made in studies on the mechanisms of action of the lipid-regulating effect of TCM in animal experiments. Current researches showed that the lipid-regulating effect of TCM may be related to the following actions: (1) inhibiting intestinal absorption of lipids; (2) reducing the biosynthesis of endogenous lipids; (3) increasing the catabolism of lipid, sterol substances in live system; (4) increasing the secretion of sterol substances in live system; (5) regulating transcription factors related to lipid metabolism. This paper provides an overview of the recent advances and discusses their implications in future development of lipid-lowering drugs from TCM.
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页数：10
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