Edical graduate education is an activity of teaching and learning to create and apply profound professional knowledge. However, current medical graduate education is following an undergraduate model, where guided teaching and hubristic teaching is scarce, curriculum is lagging, the activity of students is not high, and students lack the ability to think independently and to conduct creative science work. Therefore, there is an imperative requirement of new medical graduate education model that adapts to modern "industry-university-research" integration. This article will apply process oriented guided inquiry learning (POGIL) mode combined with massive online open classes (MOOC) to medical graduate education teaching mode reform, analyze the feasibility and strategy of the combination of the two modes. Meantime, we explored the facing problems and challenges from the combination, performing a strategic research of POGIL-MOOC combined application to improve the creative ability of medical graduates and providing powerful support for medical graduate education to cultivate innovative experts.