Upregulation of annexin A2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis

被引：11
|
作者：
Chretien, Aline [1 ]
Delaive, Edouard [1 ]
Dieu, Marc [1 ]
Demazy, Catherine [1 ]
Ninane, Noelle [1 ]
Raes, Martine [1 ]
Toussaint, Olivier [1 ]
机构：
[1] Univ Namur FUNDP, Unit Res Cellular Biol, B-5000 Namur, Belgium
来源：
EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 04期
关键词：
H2O2; senescence; fibroblasts; proteomics; membrane; annexin;
D O I：
10.1016/j.exger.2008.01.003
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Human diploid fibroblasts undergo premature senescence after treatment with sublethal concentration of H2O2. We report the first proteomic study of microsomal proteins in the context of H2O2-induced premature senescence by using 2D-DIGE approach. Twelve different proteins with altered abundance at day 3 after treatment with H2O2 were identified. Among them, we demonstrated a re-localization of annexin A2 in plasma membrane. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：353 / 359
页数：7
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