Simple, rapid procedure for the synthesis of chloromethyl methyl ether and other chloro alkyl ethers

被引:60
作者
Berliner, MA [1 ]
Belecki, K [1 ]
机构
[1] Pfizer Gloabl Res & Dev, Groton Labs, Chem Res & Dev, Groton, CT 06340 USA
关键词
D O I
10.1021/jo051344g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Zinc(II) salts catalyze the reaction between acetals and acid halides to provide haloalkyl ethers in near-quantitative yield. Reactions from millimole to mole scale are typically complete in 1-4 h with 0.01 mol % catalyst. The solutions of haloalkyl ethers thus obtained can be utilized directly in reactions in which the presence of the ester byproduct does not interfere. Excess haloalkyl ether is destroyed on workup, thereby minimizing exposure to this class of carcinogenic compounds.
引用
收藏
页码:9618 / 9621
页数:4
相关论文
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