Using binding competitors of albumin to promote the removal of protein-bound uremic toxins in hemodialysis: Hope or pipe dream?

被引：34
作者：
Florens, Nans [1 ,2 ]
Yi, Dan [1 ]
Juillard, Laurent [1 ,2 ]
Soulage, Christophe O. [1 ]
机构：
[1] Univ Lyon, INSERM, CarMeN, U1060,INSA Lyon,INRA,U1397, F-69621 Villeurbanne, France
[2] Hop Edouard Herriot, Hosp Civils Lyon, Dept Nephrol, F-69003 Lyon, France
来源：
BIOCHIMIE | 2018年 / 144卷
关键词：
Uremic toxins; Serum albumin; Protein binding; Chronic kidney disease; Hemodialysis; HUMAN SERUM-ALBUMIN; P-CRESYL SULFATE; FRACTIONATED PLASMA SEPARATION; INDOXYL SULFATE; DRUG-BINDING; PHENYLACETIC ACID; RENAL-FUNCTION; SOLUTES; CLEARANCE; SITE;
D O I：
10.1016/j.biochi.2017.09.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic kidney disease is associated with the accumulation of a large range of uremic retention solutes as referred to as uremic toxins. Some of these compounds belong to the group of Protein Bound Uremic Toxins (PBUT) due to their tight interactions with plasma proteins and especially serum albumin. These PBUT therefore exist in the bloodstream into two forms: a major bound (and non-diffusible) fraction and a minor free fraction. As a result, these compounds are poorly removed by most of the renal replacement therapies (such as hemodialysis) and their concentration can hardly be decreased in end-stage renal disease patients. An increase of the free fraction of PBUT could be achieved using chemical displacers that could compete with PBUT for binding to serum albumin. This review summarizes and discusses the interest of chemicals displacers as a valuable option to enhance PBUT removal in CKD patients. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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页码：1 / 8
页数：8
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