Precision Medicine-A Demand Signal for Genomics Education

被引:7
作者
Doll, Bruce [1 ]
De Castro, Mauricio J.
Fries, Melissa H. [2 ]
Pock, Arnyce R. [3 ]
Seibert, Diane [4 ]
Yang, Wendy [3 ]
机构
[1] Uniformed Serv Univ Hlth Sci, Off Vice President Res, Bethesda, MD 20814 USA
[2] Georgetown Univ, Medstar Washington Hosp Ctr, Sch Med, Washington, DC 20010 USA
[3] Uniformed Serv Univ Hlth Sci, E Edward Hebert Sch Med, Bethesda, MD 20814 USA
[4] Uniformed Serv Univ Hlth Sci, Daniel K Inouye Grad Sch Nursing, Bethesda, MD 20814 USA
关键词
PERSONALIZED MEDICINE; FETAL ANEUPLOIDY; GENETICS; PHYSICIANS; SEQUENCE; SERVICES;
D O I
10.1093/milmed/usab406
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pressed by the accumulating knowledge in genomics and the proven success of the translation of cancer genomics to clinical practice in oncology, the Obama administration unveiled a $215 million commitment for the Precision Medicine Initiative (PMI) in 2016, a pioneering research effort to improve health and treat disease using a new model of patient-powered research. The objectives of the initiative include more effective treatments for cancer and other diseases, creation of a voluntary national research cohort, adherence to privacy protections for maintaining data sharing and use, modernization of the regulatory framework, and forging public-private partnerships to facilitate these objectives. Specifically, the DoD Military Health System joined other agencies to execute a comprehensive effort for PMI. Of the many challenges to consider that may contribute to the implementation of genomics-lack of familiarity and understanding, poor access to genomic medicine expertise, needs for extensive informatics and infrastructure to integrate genomic results, privacy and security, and policy development to address the unique requirements of military medical practice-we will focus on the need to establish education in genomics appropriate to the provider's responsibilities. Our hypothesis is that there is a growing urgency for the development of educational experiences, formal and informal, to enable clinicians to acquire competency in genomics commensurate with their level of practice. Several educational approaches, both in practice and in development, are presented to inform decision-makers and empower military providers to pursue courses of action that respond to this need.
引用
收藏
页码:40 / 46
页数:7
相关论文
共 39 条
[1]  
Association of American Medical Colleges, MED SCH OBJ PROJ MSO
[2]   Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study [J].
Carlsson, Lena M. S. ;
Sjoholm, Kajsa ;
Jacobson, Peter ;
Andersson-Assarsson, Johanna C. ;
Svensson, Per-Arne ;
Taube, Magdalena ;
Carlsson, Bjoern ;
Peltonen, Markku .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (16) :1535-1543
[3]   Finishing the euchromatic sequence of the human genome [J].
Collins, FS ;
Lander, ES ;
Rogers, J ;
Waterston, RH .
NATURE, 2004, 431 (7011) :931-945
[4]   Preparing Medical Specialists to Practice Genomic Medicine: Education an Essential Part of a Broader Strategy [J].
Crellin, Erin ;
McClaren, Belinda ;
Nisselle, Amy ;
Best, Stephanie ;
Gaff, Clara ;
Metcalfe, Sylvia .
FRONTIERS IN GENETICS, 2019, 10
[5]   Genomic medicine in the military [J].
De Castro, Mauricio ;
Biesecker, Leslie G. ;
Turner, Clesson ;
Brenner, Ruth ;
Witkop, Catherine ;
Mehlman, Maxwell ;
Bradburne, Chris ;
Green, Robert C. .
NPJ GENOMIC MEDICINE, 2016, 1
[6]   Military genomics: a perspective on the successes and challenges of genomic medicine in the Armed Services [J].
De Castro, Mauricio J. ;
Turner, Clesson E. .
MOLECULAR GENETICS & GENOMIC MEDICINE, 2017, 5 (06) :617-620
[7]   Precision Military Medicine: Conducting a multi-site clinical utility study of genomic and lifestyle risk factors in the United States Air Force [J].
Delaney, Susan K. ;
Brenner, Ruth ;
Schmidlen, Tara J. ;
Dempsey, Michael P. ;
London, Kim E. ;
Gordon, Erynn S. ;
Bellafante, Mark ;
Nasuti, Ashley ;
Scheinfeldt, Laura B. ;
Rajula, Kaveri D. ;
Jose, Leo ;
Jarvis, Joseph P. ;
Gerry, Norman P. ;
Christman, Michael F. .
NPJ GENOMIC MEDICINE, 2017, 2
[8]   Comparing sensitivity to change using the 6-item versus the 17-item Hamilton depression rating scale in the GUIDED randomized controlled trial [J].
Dunlop, Boadie W. ;
Parikh, Sagar, V ;
Rothschild, Anthony J. ;
Thase, Michael E. ;
DeBattista, Charles ;
Conway, Charles R. ;
Forester, Brent P. ;
Mondimore, Francis M. ;
Shelton, Richard C. ;
Macaluso, Matthew ;
Logan, Jennifer ;
Traxler, Paul ;
Li, James ;
Johnson, Holly ;
Greden, John F. .
BMC PSYCHIATRY, 2019, 19 (01)
[9]   Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood [J].
Fan, H. Christina ;
Blumenfeld, Yair J. ;
Chitkara, Usha ;
Hudgins, Louanne ;
Quake, Stephen R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (42) :16266-16271
[10]  
Greco K.E., 2012, Essential genetic and genomic competencies for nurses with graduate degrees, DOI DOI 10.1891/0739-6686.29.173