共 23 条
A transgenic mouse model for Alzheimer's disease has impaired synaptic gain but normal synaptic dynamics
被引:4
作者:

Ricoy, Ulises M.
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机构:
Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA

Mao, Peizhong
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h-index: 0
机构:
Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA

Manczak, Maria
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h-index: 0
机构:
Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA

Reddy, P. Hemachandra
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h-index: 0
机构:
Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA

Frerking, Matthew E.
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h-index: 0
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Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA
机构:
[1] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA
关键词:
Hippocampus;
Synaptic;
Glutamate;
Alzheimer's;
Amyloid;
AMYLOID PRECURSOR PROTEIN;
LONG-TERM POTENTIATION;
HIPPOCAMPAL SYNAPSES;
RELEASE PROBABILITY;
A-BETA;
MICE;
TRANSMISSION;
PLASTICITY;
CORTEX;
PRESENILIN-1;
D O I:
10.1016/j.neulet.2011.06.043
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
The chronic accumulation of amyloid beta (A beta) peptides is thought to underlie much of the pathology of Alzheimer's disease (AD), and transgenic mice overexpressing A beta show both behavioral defects and impairments in hippocampal synaptic transmission. In the present study, we examined excitatory transmission at the Schaffer collateral synapse in acute hippocampal slices from APP(Swe)/PS-1(A246E) transgenic mice to determine whether the synaptic impairment in these mice is due to a reduction in the activity-independent synaptic gain, or to a change in the activity-dependent synaptic dynamics. We observed a strong reduction in synaptic transmission in slices from APP(Swe)/PS-1(A246E) mice compared to those from their wildtype littermates. However, there was no resolvable change in the synaptic dynamics observed in response to either simple or complex stimulus trains. We conclude that the chronic accumulation of A beta impairs synaptic transmission through a reduction in the synaptic gain, while preserving the synaptic dynamics. (C) 2011 Published by Elsevier Ireland Ltd.
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页码:212 / 215
页数:4
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