Crosstalk between gut microbiota and sepsis

被引：52

作者：

Niu, Mengwei ^{[1
]}

Chen, Peng ^{[1
]}

机构：

[1] Southern Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Guangdong Prov Key Lab Prote, Guangzhou 510515, Peoples R China

来源：

BURNS & TRAUMA | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

Sepsis; Microbiota; Immune; Gut barrier; Liver; Fecal microbiota transplantation; Probiotics; INTESTINAL BARRIER DYSFUNCTION; TIGHT JUNCTION PROTEINS; INTENSIVE-CARE-UNIT; HEMORRHAGIC-SHOCK; CIRCADIAN CLOCK; CELL-DEATH; MORTALITY; BACTERIA; LACTOBACILLUS; TRANSLOCATION;

D O I：

10.1093/burnst/tkab036

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Sepsis is an overwhelming inflammatory response to microbial infection. Sepsis management remains a clinical challenge. The role of the gut microbiome in sepsis has gained some attention. Recent evidence has demonstrated that gut microbiota regulate host physiological homeostasis mediators, including the immune system, gut barrier function and disease susceptibility pathways. Therefore, maintenance or restoration of microbiota and metabolite composition might be a therapeutic or prophylactic target against critical illness. Fecal microbiota transplantation and supplementation of probiotics are microbiota-based treatment methods that are somewhat limited in terms of evidence-based efficacy. This review focuses on the importance of the crosstalk between the gastrointestinal ecosystem and sepsis to highlight novel microbiota-targeted therapies to improve the outcomes of sepsis treatment.

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页数：12

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