The p110α isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival

被引：7

作者：

Rajala, Raju V. S. ^{[1
,2
,3
,4
]}

Ranjo-Bishop, Michelle ^{[1
,4
]}

Wang, Yuhong ^{[1
,4
]}

Rajala, Ammaji ^{[1
,4
]}

Anderson, Robert E. ^{[1
,3
,4
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USA

[4] Univ Oklahoma, Hlth Sci Ctr, Dean A McGee Eye Inst, Oklahoma City, OK 73104 USA

来源：

BIOCHIMIE | 2015年 / 112卷

基金：

美国国家卫生研究院;

关键词：

Phosphoinositide; 3-kinases; Phosphoinositides; Cre-loxP system; Cone photoreceptors; Retina; Vision; RETINAL DEGENERATION; RETINITIS-PIGMENTOSA; CRE RECOMBINASE; MOUSE RETINA; MICE LACKING; CELL-DEATH; LIGHT; SUBUNIT; PROTEIN; OPSIN;

D O I：

10.1016/j.biochi.2015.02.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylates the 3'OH of the inositol ring of phosphoinositides (PIs). They are responsible for coordinating a diverse range of cellular functions. Class IA PI3K is a heterodimeric protein composed of a regulatory p85 and a catalytic p110 subunit. In this study, we conditionally deleted the p110 alpha-subunit of PI3K in cone photoreceptor cells using the Cre-loxP system. Cone photoreceptors allow for color vision in bright light (daylight vision). Cone-specific deletion of p110 alpha resulted in cone degeneration. Our studies suggest that PI3K signaling is essential for cone photoreceptor functions. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

引用

页码：35 / 40

页数：6

共 47 条

[41] Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa [J].