The role of dendritic cells in immune responses against vaginal infection by herpes simplex virus type 2

被引：15
作者：
Iwasaki, A [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth & Immunobiol, New Haven, CT 06510 USA
来源：
MICROBES AND INFECTION | 2003年 / 5卷 / 13期
关键词：
mucosal immunity; genitalia; female; sexually transmitted diseases; viral; lymph nodes; Th1; cells;
D O I：
10.1016/j.micinf.2003.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Herpes simplex virus type 2 is a leading cause of genital ulcers that affects more women than men worldwide. Recent evidence indicates that protective immunity can be generated by specialized dendritic cells in the female genital mucosa. This article aims to provide an overview of the effector immunity required for protection from genital herpes, and to discuss the mechanism by which specific subsets of dendritic cells mediate induction of adaptive immunity following genital infection with herpes simplex virus type 2 in vivo. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：1221 / 1230
页数：10
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