Intensive lifestyle changes may affect the progression of prostate cancer

被引:297
作者
Ornish, D
Weidner, G
Fair, WR
Marlin, R
Pettengill, EB
Raisin, CJ
Dunn-Emke, S
Crutchfield, L
Jacobs, FN
Barnard, RJ
Aronson, WJ
McCormac, P
McKnight, DJ
Fein, JD
Dnistrian, AM
Weinstein, J
Ngo, TH
Mendell, NR
Carroll, PR
机构
[1] Univ Calif San Francisco, Res Inst Prevent Med, Sausalito, CA 94965 USA
[2] Univ Calif San Francisco, Dept Urol, Sausalito, CA 94965 USA
[3] Univ Calif San Francisco, Dept Med, Sausalito, CA 94965 USA
[4] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA USA
[5] Univ Calif Los Angeles, Dept Urol, Los Angeles, CA USA
[6] Mem Sloan Kettering Canc Ctr, Dept Urol Oncol, New York, NY 10021 USA
[7] SUNY Stony Brook, Dept Stat, Stony Brook, NY 11794 USA
[8] Windber Res Inst, Johnstown, PA USA
关键词
prostate; prostatic neoplasms; prostate-specific antigen; life style; nutrition;
D O I
10.1097/01.ju.0000169487.49018.73
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: Men with prostate cancer are often advised to make changes in diet and lifestyle, although the impact of these changes has not been well documented. Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate specific antigen (PSA), treatment trends and serum stimulated LNCaP cell growth in men with early, biopsy proven prostate cancer after 1 year. Materials and Methods: Patient recruitment was limited to men who had chosen not to undergo any conventional treatment, which provided an unusual opportunity to have a nonintervention randomized control group to avoid the confounding effects of interventions such as radiation, surgery or androgen deprivation therapy. A total of 93 volunteers with serum PSA 4 to 10 ng/ml and cancer Gleason scores less than 7 were randomly assigned to an experimental group that was asked to make comprehensive lifestyle changes or to a usual care control group. Results: None of the experimental group patients but 6 control patients underwent conventional treatment due to an increase in PSA and/or progression of disease on magnetic resonance imaging. PSA decreased 4% in the experimental group but increased 6% in the control group (p = 0.016). The growth of LNCaP prostate cancer cells (American Type Culture Collection, Manassas, Virginia) was inhibited almost 8 times more by serum from the experimental than from the control group (70% vs 9%, p <0.001). Changes in serum PSA and also in LNCaP cell growth were significantly associated with the degree of change in diet and lifestyle. Conclusions: Intensive lifestyle changes may affect the progression of early, low grade prostate cancer in men. Further studies and longer term followup are warranted.
引用
收藏
页码:1065 / 1069
页数:5
相关论文
共 20 条
  • [1] Expectant management of nonpalpable prostate cancer with curative intent: Preliminary results
    Carter, HB
    Walsh, PC
    Landis, P
    Epstein, JI
    [J]. JOURNAL OF UROLOGY, 2002, 167 (03) : 1231 - 1234
  • [2] Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: Exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features
    Demark-Wahnefried, W
    Price, DT
    Polascik, TJ
    Robertson, CN
    Anderson, EE
    Paulson, DF
    Walther, PJ
    Gannon, M
    Vollmer, RT
    [J]. UROLOGY, 2001, 58 (01) : 47 - 52
  • [3] DUNNEMKE S, 2005, J AM DIET ASSOC, V105, P1350
  • [4] Dietary manipulation, ethnicity, and serum PSA levels
    Eastham, JA
    Riedel, E
    Latkany, L
    Fleisher, M
    Schatzkin, A
    Lanza, E
    Shike, M
    [J]. UROLOGY, 2003, 62 (04) : 677 - 682
  • [5] Giovannucci E, 2002, JNCI-J NATL CANCER I, V94, P391, DOI 10.1093/jnci/94.5.391
  • [6] Patterns of treatment of patients with prostate cancer initially managed with surveillance: Results from the CaPSURE database
    Koppie, TM
    Grossfeld, GD
    Miller, D
    Yu, J
    Stier, D
    Broering, JM
    Lubeck, D
    Henning, JM
    Flanders, SC
    Carroll, PR
    [J]. JOURNAL OF UROLOGY, 2000, 164 (01) : 81 - 88
  • [7] Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro
    Leung, PS
    Aronson, WJ
    Ngo, TH
    Golding, LA
    Barnard, RJ
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2004, 96 (02) : 450 - 454
  • [8] Nilsen TIL, 2000, BRIT J CANCER, V82, P1358
  • [9] Intensive lifestyle changes for reversal of coronary heart disease
    Ornish, D
    Scherwitz, LW
    Billings, JH
    Gould, KL
    Merritt, TA
    Sparler, S
    Armstrong, WT
    Ports, TA
    Kirkeeide, RL
    Hogeboom, C
    Brand, RJ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (23): : 2001 - 2007
  • [10] ORNISH D, 2002, HARRISONS ADV CARDIO