The objective of the present study was to determine factors that may explain healthy lifestyles in university students, so to establish programs for health promoting lifestyles in educational institutions. A cross-sectional descriptive study was applied in seven universities from Colombia's Caribbean coast within the framework of the Programs for wellness and health promoting lifestyles for university students. A total of 2203 university students from undergraduate academic programs at each university took part in the study. The FANTASTIC questionnaire was used to measure lifestyles. In addition, a survey to evaluate sociodemographic and academic variables was filled. A percentage of 9% of the students have excellent lifestyle, and 46% were assessed as good. Based on the Multivariate regression approach, we observed that women are more inactive [OR 1,5 (IC 95% 1,1-1,9)] and they have also low quality of sleep [OR 1,4 (IC 95% 1,1-1,6)]. Younger students consume tobacco [OR 1,4 (IC 95% 1,1-1,9)] they do not sleep well and show inability to manage stress [OR 2,1 (IC 95% 1,5-2,9)]. Students from the lowest socio-economic stratum have more probability of lower consumption of fruits and vegetables but higher consumption of salt, fat, and sugar [OR 1,7 (IC 95% 1,1-2,8)]. Lifestyles related to health in university students might be explained by socio-demographic and academic factors. Improvement strategies for lifestyles based on programs for health promotion in universities are imperative.