Pico calorimeter for detection of heat produced in an individual brown fat cell

被引：72

作者：

Inomata, Naoki ^{[1
]}

Toda, Masaya ^{[1
,2
]}

Sato, Masaaki ^{[3
]}

Ishijima, Akihiko ^{[3
]}

Ono, Takahito ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Engn, Sendai, Miyagi 9808579, Japan

[2] Tohoku Univ, Microsyst Integrat Ctr, Sendai, Miyagi 9808579, Japan

[3] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Sendai, Miyagi 9808577, Japan

来源：

APPLIED PHYSICS LETTERS | 2012年 / 100卷 / 15期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

ADIPOCYTES;

D O I：

10.1063/1.3701720

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

A pico calorimeter with a highly sensitive sensor for detecting heat from a biological cell is developed and evaluated, and also the heat detection of a single brown fat cell has been demonstrated. The measurement principle relies on resonant frequency tracking of a resonator in temperature variation due to the heat from the sample; the resonator is placed in vacuum, and heat is conducted from the sample in the microfluidic channel via a heat guide. This configuration can prevent heat loss from the resonator to the surroundings and damping in water. The heat resolution of the fabricated sensor is 5.2 pJ. Heat emissions from single cells are detected as pulsed or continuous in the absence and presence of stimulation, respectively. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3701720]

引用

页数：4

共 18 条

[1] TIME AND FREQUENCY (TIME-DOMAIN) CHARACTERIZATION, ESTIMATION, AND PREDICTION OF PRECISION CLOCKS AND OSCILLATORS [J].