Breast cancer following diethylstilbestrol exposure in utero: insights from a tragedy

被引：21

作者：

Adami, Hans-Olov ^{[2
,3
]}

Lagiou, Pagona ^{[1
,2
]}

Trichopoulos, Dimitrios ^{[2
]}

机构：

[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[3] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2012年 / 27卷 / 01期

关键词：

Diethylstilbestrol; DES; Estrogens; In utero; Breast cancer; YOUNG-WOMEN; RISK; EPIDEMIOLOGY;

D O I：

10.1007/s10654-012-9655-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Diethylstilbestrol (DES), a powerful synthetic estrogen introduced in 1938, was prescribed to prevent pregnancy complications, but was later shown to have a series of adverse side-effects in the offspring, including cancer of the vagina. Recent evidence indicates that in utero exposure to DES is also linked to breast cancer in women over the age of 40 years. This evidence provides support to the hypothesis that in utero exposures may affect breast cancer risk in adult life.

引用

页码：1 / 3

页数：3

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