Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

被引：44
作者：
Iwase, Y
Takemura, Y
Ju-ichi, M
Mukainaka, T
Ichiishi, E
Ito, C
Furukawa, H
Yano, M
Tokuda, H
Nishino, H
机构：
[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
[3] Meijo Univ, Fac Pharm, Nagoya, Aichi 4688503, Japan
[4] Natl Inst Fruit Tree Sci, Shizuoka 4240292, Japan
来源：
CANCER LETTERS | 2001年 / 173卷 / 02期
关键词：
flavonoid derivative; quercetin pentaallyl ether; anti-tumor promoter; two-stage carcinogenesis;
D O I：
10.1016/S0304-3835(01)00615-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To search for possible anti-tumor promoters, ten flavonoid derivatives (1-10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：105 / 109
页数：5
相关论文
共 9 条
[1]   Citrus polymethoxylated flavones can confer resistance against Phytophthora citrophthora, Penicillium digitatum, and Geotrichum species [J].
Del Río, JA ;
Arcas, MC ;
Benavente-García, O ;
Ortuño, A .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (10) :4423-4428
[2]   IMMUNOFLUORESCENCE IN CELLS DERIVED FROM BURKITTS LYMPHOMA [J].
HENLE, G ;
HENLE, W .
JOURNAL OF BACTERIOLOGY, 1966, 91 (03) :1248-&
[3]   Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells [J].
Ikegawa, T ;
Ushigome, F ;
Koyabu, N ;
Morimoto, S ;
Shoyama, Y ;
Naito, M ;
Tsuruo, T ;
Ohtani, H ;
Sawada, Y .
CANCER LETTERS, 2000, 160 (01) :21-28
[4]   A SHORT-TERM INVITRO ASSAY FOR PROMOTER SUBSTANCES USING HUMAN-LYMPHOBLASTOID CELLS LATENTLY INFECTED WITH EPSTEIN-BARR VIRUS [J].
ITO, Y ;
YANASE, S ;
FUJITA, J ;
HARAYAMA, T ;
TAKASHIMA, M ;
IMANAKA, H .
CANCER LETTERS, 1981, 13 (01) :29-37
[5]   Cancer chemopreventive activity of 3,5,6,7,8,3′,4′-heptamethoxyflavone from the peel of citrus plants [J].
Iwase, Y ;
Takemura, Y ;
Ju-ichi, M ;
Yano, M ;
Ito, C ;
Furukawa, H ;
Mukainaka, T ;
Kuchide, M ;
Tokuda, H ;
Nishino, H .
CANCER LETTERS, 2001, 163 (01) :7-9
[6]   Inhibitory effect of flavonoids from Citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors [J].
Iwase, Y ;
Takemura, Y ;
Ju-ichi, M ;
Ito, C ;
Furukawa, H ;
Kawaii, S ;
Yano, M ;
Mou, XY ;
Takayasu, J ;
Tokuda, H ;
Nishino, H .
CANCER LETTERS, 2000, 154 (01) :101-105
[7]  
Kawaii S, 1999, ANTICANCER RES, V19, P1261
[8]   Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-α expression by human monocytes [J].
Manthey, JA ;
Grohmann, K ;
Montanari, A ;
Ash, K ;
Manthey, CL .
JOURNAL OF NATURAL PRODUCTS, 1999, 62 (03) :441-444
[9]   INHIBITORY EFFECTS OF URSOLIC AND OLEANOLIC ACID ON SKIN TUMOR PROMOTION BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE [J].
TOKUDA, H ;
OHIGASHI, H ;
KOSHIMIZU, K ;
ITO, Y .
CANCER LETTERS, 1986, 33 (03) :279-285
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